<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Glyphosate, in the commercial formulation named Roundup, is a broad spectrum herbicide that is one of the most frequently applied pesticides in the world. However, there has been little evidence of Roundup toxicity or genotoxicity. Genotoxicity of glyphosate was carried out using the <italic>Escherichia coli</italic> SOS chromotest. The glyphosate-induced dose response in the SOS chromotest suggests that glyphosate possesses genotoxic properties. Glyphosate at a 0.2 g/l concentration in toxicity bioassay caused 50% mortality of Daphnia magna (LD50 after 24 h — 0.22 g/l; after 48 h — 0.19 g/l), but 0.25 — 0.5 g/l — 100% death of organisms (LD100 after 24 h — 0.5 g/l; after 48 h — 0.25 g/l). Our results (<italic>E. coli</italic> SOS chromotest and daphnia test system) together with recent animal studies and epidemiological reports suggest that glyphosate, especially, Roundup possesses both toxic and genotoxic properties.</p></abstract>

Glyphosate, in the commercial formulation named Roundup, is a broad spectrum herbicide that is one of the most frequently applied pesticides in the world. However, there has been little evidence of Roundup toxicity or genotoxicity. Genotoxicity of glyphosate was carried out using the Escherichia coli SOS chromotest. The glyphosate-induced dose response in the SOS chromotest suggests that glyphosate possesses genotoxic properties. Glyphosate at a 0.2 g/l concentration in toxicity bioassay caused 50% mortality of Daphnia magna (LD50 after 24 h — 0.22 g/l; after 48 h — 0.19 g/l), but 0.25 — 0.5 g/l — 100% death of organisms (LD100 after 24 h — 0.5 g/l; after 48 h — 0.25 g/l). Our results (E. coli SOS chromotest and daphnia test system) together with recent animal studies and epidemiological reports suggest that glyphosate, especially, Roundup possesses both toxic and genotoxic properties.

Toxicity and Genotoxicity Testing of Roundup

Institute of Microbiology and Biotechnology, University of Latvia, Kronvalda bulv. 4, Riga, LV-1586, LATVIA

Institute of Aquatic Ecology, University of Latvia, Daugavgrīvas 8, Riga, LV-1048, LATVIA

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

{"article-title":"Toxicity and Genotoxicity Testing of Roundup"}

Glyphosate, in the commercial formulation named Roundup, is a broad spectrum herbicide that is one of the most frequently applied pesticides in the world....

Toxicity and Genotoxicity Testing of Roundup

Published Online: Jul 08, 2009

Page range: 29 - 32

DOI: https://doi.org/10.2478/v10046-009-0009-6

Keywords
glyphosate (Roundup), toxicity, genotoxicity, SOS chromotest, toxicity bioassay

This content is open access.

Toxicity and Genotoxicity Testing of Roundup

Published Online: Jul 08, 2009

Page range: 29 - 32

DOI: https://doi.org/10.2478/v10046-009-0009-6

Keywordsglyphosate (Roundup), toxicity, genotoxicity, SOS chromotest, toxicity bioassay

This content is open access.

Keywords
glyphosate (Roundup), toxicity, genotoxicity, SOS chromotest, toxicity bioassay