<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Over the last few years, evidence has been accumulated that several susceptibility genes exist that differentially impact on the lifetime risk for breast or ovarian cancer. High-to-moderate penetrance alleles have been identified in genes involved in DNA double-strand break signaling and repair, and many low-penetrance susceptibility loci have been identified through genome-wide association studies. In this review, we briefly summarize present knowledge about breast and ovarian cancer susceptibility genes and discuss their implications for risk prediction and therapy.</p></abstract>

Over the last few years, evidence has been accumulated that several susceptibility genes exist that differentially impact on the lifetime risk for breast or ovarian cancer. High-to-moderate penetrance alleles have been identified in genes involved in DNA double-strand break signaling and repair, and many low-penetrance susceptibility loci have been identified through genome-wide association studies. In this review, we briefly summarize present knowledge about breast and ovarian cancer susceptibility genes and discuss their implications for risk prediction and therapy.

Molecular Genetics of Breast and Ovarian Cancer: Recent Advances and Clinical Implications

Hannover Medical School, Gynaecology Research Unit (OE 6411), Carl-Neuberg-Str. 1, D-30625 Hannover, Germany

Clinic of Radiation Oncology, Hannover Medical School, Hannover, Germany

Clinic of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany

Balkan Journal of Medical Genetics

Over the last few years, evidence has been accumulated that several susceptibility genes exist that differentially impact on the lifetime risk for breast or...

Molecular Genetics of Breast and Ovarian Cancer: Recent Advances and Clinical Implications

Published Online: Dec 22, 2012

Page range: 75 - 80

DOI: https://doi.org/10.2478/v10034-012-0024-9

This content is open access.