<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><bold>Objectives:</bold> To look for a possible association of maternal haemorrhoid during pregnancy with a risk of congenital abnormalities in their children.<bold>Methods:</bold> Comparison of the prevalence of medically-recorded haemorrhoid in pregnant women who had fetuses/newborns (cases) with congenital abnormalities and healthy babies (controls) in the population-based Hungarian Case-Control Surveillance System of Congenital Abnormalities.<bold>Results:</bold> Of 22,843 cases with congenital abnormalities, 798 (3.49%), while of 38,151 controls, 1,624 (4.26%) had mothers with recorded and usually treated severe haemorrhoids. We found a higher risk for exomphalos (OR with 95% CI: 4.9, 1.7-7.9), and malposition-malrotation of gut (OR with 95% CI: 17.2, 2.1-142.0) which were present in 14 and 8 children of pregnant women with haemorrhoid, respectively. These associations could not be explained by teratogenic effect of maternal haemorrhoid or by drug treatments, so we hypothesized a possible common genetic background.<bold>Conclusions:</bold> The higher frequency of exomphalos and malposition-malrotation of gut found in the children of mothers with haemorrhoid during pregnancy requires further study.</abstract>

Objectives: To look for a possible association of maternal haemorrhoid during pregnancy with a risk of congenital abnormalities in their children.Methods: Comparison of the prevalence of medically-recorded haemorrhoid in pregnant women who had fetuses/newborns (cases) with congenital abnormalities and healthy babies (controls) in the population-based Hungarian Case-Control Surveillance System of Congenital Abnormalities.Results: Of 22,843 cases with congenital abnormalities, 798 (3.49%), while of 38,151 controls, 1,624 (4.26%) had mothers with recorded and usually treated severe haemorrhoids. We found a higher risk for exomphalos (OR with 95% CI: 4.9, 1.7-7.9), and malposition-malrotation of gut (OR with 95% CI: 17.2, 2.1-142.0) which were present in 14 and 8 children of pregnant women with haemorrhoid, respectively. These associations could not be explained by teratogenic effect of maternal haemorrhoid or by drug treatments, so we hypothesized a possible common genetic background.Conclusions: The higher frequency of exomphalos and malposition-malrotation of gut found in the children of mothers with haemorrhoid during pregnancy requires further study.

Possible Association of Maternal Haemorrhoid with Congenital Abnormalities in their Children - a Population-Based Case-Control Study

Second Department of Obstetrics and Gynecology, Semmelweis, University, School of Medicine, Budapest, Hungary

Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary

Balkan Journal of Medical Genetics

Objectives: To look for a possible association of maternal haemorrhoid during pregnancy with a risk of congenital abnormalities in their children.Methods:...

Possible Association of Maternal Haemorrhoid with Congenital Abnormalities in their Children - a Population-Based Case-Control Study

Published Online: Aug 25, 2010

Page range: 23 - 33

DOI: https://doi.org/10.2478/v10034-010-0015-7

Keywords
Haemorrhoid, Related drug treatment, Pregnancy, Maternal effect, Congenital abnormalities, Exomphalos, Malposition-malrotation of gut, Population-based case-control study

This content is open access.

Possible Association of Maternal Haemorrhoid with Congenital Abnormalities in their Children - a Population-Based Case-Control Study

Published Online: Aug 25, 2010

Page range: 23 - 33

DOI: https://doi.org/10.2478/v10034-010-0015-7

KeywordsHaemorrhoid, Related drug treatment, Pregnancy, Maternal effect, Congenital abnormalities, Exomphalos, Malposition-malrotation of gut, Population-based case-control study

This content is open access.

Keywords
Haemorrhoid, Related drug treatment, Pregnancy, Maternal effect, Congenital abnormalities, Exomphalos, Malposition-malrotation of gut, Population-based case-control study