<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Several host genes proven to contribute to active tuberculosis (TB) and some of the localized major susceptibility loci, which influence lung cancer (LC) risk, are of considerable scientific interest, but do not confer high enough risk to be clinically relevant. Assuming that these diseases are genetically controlled, we hypothesized that retreat from optimal homozygosity level, as well as a changed variability among the patients, could be the populationgenetic parameter for prediction of illness. We performed a homozygous-recessive-characters (HRCs) test based analysis of the presence, distribution and individual combination of 23 selected genetically-controlled morpho-physiological traits in groups of LC patients, patients with pulmonary TB and healthy control subjects. This study showed: <italic><bold>i</bold></italic>) a statistically significant difference of the middle values of genetic homozygosity between both patients groups and the control group, <italic><bold>ii</bold></italic>) differences in the type of distribution, and <italic><bold>iii</bold></italic>) differences in the presence of certain individual combinations of such traits. The frequency of blood group O was significantly decreased in the TB group compared to the general population. According to their population-genetic structure, LC patients, TB patients and healthy controls represent three different groups. The retreat from optimal homozygosity level towards decrease that we found in both LC and TB patients support the influence of a dominant factor in development of these diseases.</p></abstract>

Several host genes proven to contribute to active tuberculosis (TB) and some of the localized major susceptibility loci, which influence lung cancer (LC) risk, are of considerable scientific interest, but do not confer high enough risk to be clinically relevant. Assuming that these diseases are genetically controlled, we hypothesized that retreat from optimal homozygosity level, as well as a changed variability among the patients, could be the populationgenetic parameter for prediction of illness. We performed a homozygous-recessive-characters (HRCs) test based analysis of the presence, distribution and individual combination of 23 selected genetically-controlled morpho-physiological traits in groups of LC patients, patients with pulmonary TB and healthy control subjects. This study showed: i) a statistically significant difference of the middle values of genetic homozygosity between both patients groups and the control group, ii) differences in the type of distribution, and iii) differences in the presence of certain individual combinations of such traits. The frequency of blood group O was significantly decreased in the TB group compared to the general population. According to their population-genetic structure, LC patients, TB patients and healthy controls represent three different groups. The retreat from optimal homozygosity level towards decrease that we found in both LC and TB patients support the influence of a dominant factor in development of these diseases.

Lung Cancer and Pulmonary Tuberculosis - A Comparative Population-Genetic Study

School of Medicine University of Belgrade, Belgrade, Serbia

Institute of Lung Diseases and Tuberculosis, Research and Epidemiology Department, Clinical Centre of Serbia, Belgrade, Serbia

Serbian Academy of Sciences and Arts, Belgrade, Serbia

Balkan Journal of Medical Genetics

{"article-title":"Lung Cancer and Pulmonary Tuberculosis - A Comparative Population-Genetic Study"}

Several host genes proven to contribute to active tuberculosis (TB) and some of the localized major susceptibility loci, which influence lung cancer (LC) risk,...

Lung Cancer and Pulmonary Tuberculosis - A Comparative Population-Genetic Study

Published Online: Feb 19, 2010

Page range: 45 - 52

DOI: https://doi.org/10.2478/v10034-010-0003-y

Keywords
Genetic predisposition, Lung cancer (LC), Tuberculosis (TB), Phenotype, Marker, Population genetic

This content is open access.

Lung Cancer and Pulmonary Tuberculosis - A Comparative Population-Genetic Study

Published Online: Feb 19, 2010

Page range: 45 - 52

DOI: https://doi.org/10.2478/v10034-010-0003-y

KeywordsGenetic predisposition, Lung cancer (LC), Tuberculosis (TB), Phenotype, Marker, Population genetic

This content is open access.

Keywords
Genetic predisposition, Lung cancer (LC), Tuberculosis (TB), Phenotype, Marker, Population genetic