<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><bold>Background.</bold> The early determination of premalignant lesions of pancreas can prevent unnecessary excessive surgical procedures and can reduce morbidity and mortality. Pancreatic intraepithelial neoplasia-3 (PanIN-3) is a preinvasive form of adenocarcinoma (carcinoma <italic>in situ</italic>). PanINs have not taken place in the literature of radiology yet, it should be considered in differential diagnosis of pancreatic cystic lesions.<bold>Case report.</bold> A patient with preliminary diagnosis of chronic cholecystitis who had choledocolithiasis and periampullary pancreatic cyst detected by noncontrast-enhanced (NCE) and contrast-enhanced (CE) magnetic resonance cholangiography (MRCP) is presented. Pathological examination results of gallbladder and pancreatic cyst were reported as gallbladder adenocarcinoma and PanIN-3, respectively.<bold>Conclusions.</bold> Pancreatic cystic lesions with thin septa which enhances slightly with the administration of contrast material may represent PanIN-3. In patients with cystic pancreatic lesion localized at periampullary region, using CE-MRCP together with NCE-MRCP could be useful in the evaluation of pancreatic cystic masses as well as other abdominal pathologies.</abstract>

Background. The early determination of premalignant lesions of pancreas can prevent unnecessary excessive surgical procedures and can reduce morbidity and mortality. Pancreatic intraepithelial neoplasia-3 (PanIN-3) is a preinvasive form of adenocarcinoma (carcinoma in situ). PanINs have not taken place in the literature of radiology yet, it should be considered in differential diagnosis of pancreatic cystic lesions.Case report. A patient with preliminary diagnosis of chronic cholecystitis who had choledocolithiasis and periampullary pancreatic cyst detected by noncontrast-enhanced (NCE) and contrast-enhanced (CE) magnetic resonance cholangiography (MRCP) is presented. Pathological examination results of gallbladder and pancreatic cyst were reported as gallbladder adenocarcinoma and PanIN-3, respectively.Conclusions. Pancreatic cystic lesions with thin septa which enhances slightly with the administration of contrast material may represent PanIN-3. In patients with cystic pancreatic lesion localized at periampullary region, using CE-MRCP together with NCE-MRCP could be useful in the evaluation of pancreatic cystic masses as well as other abdominal pathologies.

Periampullary localized pancreatic intraepithelial neoplasia-3 (PanIN-3): evaluation with contrast-enhanced MR cholangiography (MRCP)

Department of Radiology, Atatürk Training and Research Hospital, Bilkent, Ankara, Turkey

Department of General Surgery, Atatürk Training and Research Hospital, Bilkent, Ankara, Turkey

Radiology and Oncology

Background. The early determination of premalignant lesions of pancreas can prevent unnecessary excessive surgical procedures and can reduce morbidity and...

Periampullary localized pancreatic intraepithelial neoplasia-3 (PanIN-3): evaluation with contrast-enhanced MR cholangiography (MRCP)

Published Online: Nov 16, 2011

Page range: 300 - 303

DOI: https://doi.org/10.2478/v10019-011-0035-2

Keywords
multidetector computed tomography, pancreatic cysts, magnetic resonance cholangiography, carcinoma, pancreatic intraepithelial neoplasia, magnetic resonance imaging

This content is open access.

Periampullary localized pancreatic intraepithelial neoplasia-3 (PanIN-3): evaluation with contrast-enhanced MR cholangiography (MRCP)

Published Online: Nov 16, 2011

Page range: 300 - 303

DOI: https://doi.org/10.2478/v10019-011-0035-2

Keywordsmultidetector computed tomography, pancreatic cysts, magnetic resonance cholangiography, carcinoma, pancreatic intraepithelial neoplasia, magnetic resonance imaging

This content is open access.

Keywords
multidetector computed tomography, pancreatic cysts, magnetic resonance cholangiography, carcinoma, pancreatic intraepithelial neoplasia, magnetic resonance imaging