<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><bold><italic>Background.</italic></bold> The aim of this study is to assess an easy and quick method on simulating chromosome breaks in cells exposed to heavy charged particles.<bold><italic>Methods.</italic></bold> The theoretical value of chromosome break was calculated, and the validated comparison with the experimental value by using a premature chromosome condensation technique was done.<bold><italic>Results.</italic></bold> A good consistence was found to be appeared between the theoretical and experimental value.<bold><italic>Conclusions.</italic></bold> This suggested that a higher relative biological effectiveness of heavy ions was closely correlated with its physical characteristics and besides, a safe approach on predicting chromosome breaks in cells exposed to heavy ions at off-line environment come to be considered. Furthermore, three key factors influencing the theoretical simulation was investigated and discussed.</abstract>

Background. The aim of this study is to assess an easy and quick method on simulating chromosome breaks in cells exposed to heavy charged particles.Methods. The theoretical value of chromosome break was calculated, and the validated comparison with the experimental value by using a premature chromosome condensation technique was done.Results. A good consistence was found to be appeared between the theoretical and experimental value.Conclusions. This suggested that a higher relative biological effectiveness of heavy ions was closely correlated with its physical characteristics and besides, a safe approach on predicting chromosome breaks in cells exposed to heavy ions at off-line environment come to be considered. Furthermore, three key factors influencing the theoretical simulation was investigated and discussed.

A method on theoretical simulation of chromosome breaks in cells exposed to heavy ions

Institute of Modern Physics, Chinese Academy of Sciences, LAN Zhou

Life Science School of Northwest Normal University, LAN Zhou

Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China

Radiology and Oncology

Background. The aim of this study is to assess an easy and quick method on simulating chromosome breaks in cells exposed to heavy charged particles.Methods....

A method on theoretical simulation of chromosome breaks in cells exposed to heavy ions

Published Online: Mar 27, 2008

Page range: 32 - 38

DOI: https://doi.org/10.2478/v10019-007-0036-3

Keywords
theoretical simulation, chromosome breaks, cells, heavy ions

This content is open access.

A method on theoretical simulation of chromosome breaks in cells exposed to heavy ions

Published Online: Mar 27, 2008

Page range: 32 - 38

DOI: https://doi.org/10.2478/v10019-007-0036-3

Keywordstheoretical simulation, chromosome breaks, cells, heavy ions

This content is open access.

Keywords
theoretical simulation, chromosome breaks, cells, heavy ions