<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>The effect of supplementation with a fixed combination of antioxidants (beta-carotene, selenium, vitamins C and E) on serum lipids was monitored in patients with newly detected Graves' disease. Measurements were made prior to the commencement of therapy and after 30 and 60 days. Patients were randomized into two groups. Test group comprised patients who received antioxidant supplementation in addition to methimazole, while patients treated with methimazole only were in the control group. The concentration of total and HDL-cholesterol increased significantly in test and control groups (<italic>p</italic> &lt; 0.05) but these groups did not differ significantly. Concentration of LDL-cholesterol increased significantly in the test group only (<italic>p</italic> &lt; 0.005) and was significantly different from the control group 60 days after the commencement of therapy (<italic>p</italic> &lt; 0.005). Significant increase in the LDL-cholesterol concentration in the test group requires further investigations.</p></abstract>

The effect of supplementation with a fixed combination of antioxidants (beta-carotene, selenium, vitamins C and E) on serum lipids was monitored in patients with newly detected Graves' disease. Measurements were made prior to the commencement of therapy and after 30 and 60 days. Patients were randomized into two groups. Test group comprised patients who received antioxidant supplementation in addition to methimazole, while patients treated with methimazole only were in the control group. The concentration of total and HDL-cholesterol increased significantly in test and control groups (p < 0.05) but these groups did not differ significantly. Concentration of LDL-cholesterol increased significantly in the test group only (p < 0.005) and was significantly different from the control group 60 days after the commencement of therapy (p < 0.005). Significant increase in the LDL-cholesterol concentration in the test group requires further investigations.

Antioxidant supplementation and serum lipids in patients with Graves' disease: Effect on LDL-cholesterol

Department of Clinical Pharmacy, Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia

Department of Medical Biochemistry, University Hospital «Sestre milosrdnice», Zagreb, Croatia

Department of Nuclear Medicine, University Hospital Dubrava, Zagreb, Croatia

Department of Endocrinology, University Hospital Dubrava, Zagreb, Croatia

Department of Pharmacology, University Hospital Dubrava, Zagreb, Croatia

Acta Pharmaceutica

The effect of supplementation with a fixed combination of antioxidants (beta-carotene, selenium, vitamins C and E) on serum lipids was monitored in patients...

Antioxidant supplementation and serum lipids in patients with Graves' disease: Effect on LDL-cholesterol

Published Online: Apr 03, 2012

Page range: 115 - 122

DOI: https://doi.org/10.2478/v10007-012-0005-2

Keywords
Gravesova bolest, antioksidansi, serumski lipidi, LDL-kolesterol

This content is open access.

Antioxidant supplementation and serum lipids in patients with Graves' disease: Effect on LDL-cholesterol

Published Online: Apr 03, 2012

Page range: 115 - 122

DOI: https://doi.org/10.2478/v10007-012-0005-2

KeywordsGravesova bolest, antioksidansi, serumski lipidi, LDL-kolesterol

This content is open access.

Keywords
Gravesova bolest, antioksidansi, serumski lipidi, LDL-kolesterol