1. bookVolume 61 (2011): Issue 3 (September 2011)
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eISSN
1846-9558
ISSN
1330-0075
First Published
28 Feb 2007
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4 times per year
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English
access type Open Access

Antitumor and anti-inflammatory activities of polysaccharides isolated from Ganoderma lucidum

Published Online: 26 Sep 2011
Volume & Issue: Volume 61 (2011) - Issue 3 (September 2011)
Page range: 335 - 342
Journal Details
License
Format
Journal
eISSN
1846-9558
ISSN
1330-0075
First Published
28 Feb 2007
Publication timeframe
4 times per year
Languages
English
Antitumor and anti-inflammatory activities of polysaccharides isolated from <italic>Ganoderma lucidum</italic>

In this study, polysaccharides were isolated from Ganoderma lucidum (Polyporaceae) and their antitumor and anti-inflammatory activities were investigated using in vivo models. Potential antitumor activity was shown by G. lucidum polysaccharides (GLP) against solid tumor induced by Ehrlich's ascites carcinoma cells. GLP at 100 mg kg-1 body mass showed 80.8 and 77.6 % reduction in tumour volume and tumour mass, respectively, when administered 24 h after tumour implantation. Again, GLP at the same dose but when administered prior to tumour inoculation, showed 79.5 and 81.2 % inhibition of tumour volume and tumour mass, respectively. GLP showed significant dose-dependent activity in carrageenean-induced (acute) and formalin-induced (chronic) inflammation assays. At 100 mg kg-1, GLP exhibited 57.6 and 58.2 % inhibition in carrageenean-induced and formalin-induced assays, respectively.

Keywords

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