<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Biodegradable implants of ciprofloxacin hydrochloride for post operative site delivery were prepared using glyceryl monostearate and different concentrations of polyethylene glycol (PEG 6000), glycerol and Tween 80 as erosion enhancers by compression and molding technique. Formulations were subjected to <italic>in vitro</italic> drug release by the USP dissolution method, while promising formulations were subjected to <italic>in vitro</italic> drug release by the agar gel method and also to stability studies. It was observed that glyceryl monostearate formed hydrophobic matrix and delayed the drug delivery. Antibiotic release profile was controlled by using different combinations of erosion enhancers. The formulation prepared by the compression method showed more delayed release compared to formulations prepared by the molding method.</p></abstract>

Biodegradable implants of ciprofloxacin hydrochloride for post operative site delivery were prepared using glyceryl monostearate and different concentrations of polyethylene glycol (PEG 6000), glycerol and Tween 80 as erosion enhancers by compression and molding technique. Formulations were subjected to in vitro drug release by the USP dissolution method, while promising formulations were subjected to in vitro drug release by the agar gel method and also to stability studies. It was observed that glyceryl monostearate formed hydrophobic matrix and delayed the drug delivery. Antibiotic release profile was controlled by using different combinations of erosion enhancers. The formulation prepared by the compression method showed more delayed release compared to formulations prepared by the molding method.

Formulation and evaluation of controlled release antibiotic biodegradable implants for post operative site delivery

Sharad Pawar College of Pharmacy Wanadongri, Hingna road Nagpur-441110 (M.S.), India

Acta Pharmaceutica

Biodegradable implants of ciprofloxacin hydrochloride for post operative site delivery were prepared using glyceryl monostearate and different concentrations...

Formulation and evaluation of controlled release antibiotic biodegradable implants for post operative site delivery

Published Online: Mar 13, 2010

Page range: 111 - 117

DOI: https://doi.org/10.2478/v10007-010-0005-z

Keywords
biorazgradljivi implantati antibiotika, gliceril monostearat, kontrolirano oslobadanje, mjesto isporuke, promotor erozije

This content is open access.

Formulation and evaluation of controlled release antibiotic biodegradable implants for post operative site delivery

Published Online: Mar 13, 2010

Page range: 111 - 117

DOI: https://doi.org/10.2478/v10007-010-0005-z

Keywordsbiorazgradljivi implantati antibiotika, gliceril monostearat, kontrolirano oslobadanje, mjesto isporuke, promotor erozije

This content is open access.

Keywords
biorazgradljivi implantati antibiotika, gliceril monostearat, kontrolirano oslobadanje, mjesto isporuke, promotor erozije