<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>A biphasic gastroretentive drug delivery system of fenoverine was developed to maintain constant plasma concentration. The delivery system consisted of a loading-dose tablet and a floating multiple matrix tablet prepared by the direct compression process. The drug release from biphasic GRDDS in 0.1 mol L<sup>-1</sup> HCl and SGF (enzyme free) was sustained over 12 h with buoyant properties. Stability studies showed no significant change in dissolution profiles (<italic>f</italic>2 value > 50). Based on the release kinetics, it can be concluded that the floating multiple matrix tablet containing HPMC was a particularly suitable gastroretentive drug delivery system with a zero-order release profile.</p></abstract>

A biphasic gastroretentive drug delivery system of fenoverine was developed to maintain constant plasma concentration. The delivery system consisted of a loading-dose tablet and a floating multiple matrix tablet prepared by the direct compression process. The drug release from biphasic GRDDS in 0.1 mol L-1 HCl and SGF (enzyme free) was sustained over 12 h with buoyant properties. Stability studies showed no significant change in dissolution profiles (f2 value > 50). Based on the release kinetics, it can be concluded that the floating multiple matrix tablet containing HPMC was a particularly suitable gastroretentive drug delivery system with a zero-order release profile.

Formulation and evaluation of multiple tablets as a biphasic gastroretentive floating drug delivery system for fenoverine

Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences Kakatiya University, Warangal-506009 (A.P.), India

Acta Pharmaceutica

A biphasic gastroretentive drug delivery system of fenoverine was developed to maintain constant plasma concentration. The delivery system consisted of a...

Formulation and evaluation of multiple tablets as a biphasic gastroretentive floating drug delivery system for fenoverine

Published Online: Mar 13, 2010

Page range: 89 - 97

DOI: https://doi.org/10.2478/v10007-010-0001-3

Keywords
bifazično oslobadanje, zadržavanje u želucu, viseslojne matriksne tablete, kinetika oslobadanja

This content is open access.

Formulation and evaluation of multiple tablets as a biphasic gastroretentive floating drug delivery system for fenoverine

Published Online: Mar 13, 2010

Page range: 89 - 97

DOI: https://doi.org/10.2478/v10007-010-0001-3

Keywordsbifazično oslobadanje, zadržavanje u želucu, viseslojne matriksne tablete, kinetika oslobadanja

This content is open access.

Keywords
bifazično oslobadanje, zadržavanje u želucu, viseslojne matriksne tablete, kinetika oslobadanja