<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>The purpose of the present research work was to observe the effects of drug solubility on their release kinetics of water soluble verpamil hydrochloride and insoluble aceclofenac from hydrophilic polymer based matrix formulations. Matrix formulations were prepared by the direct compression method. The formulations were evaluated for various physical parameters. Along with the dynamics of water uptake and erosion, SEM and <italic>in vitro</italic> drug release of the tablets were studied. Applying an exponential equation, it was found that the kinetics of soluble drug release followed anomalous non-Fickian diffusion transport whereas insoluble drug showed zero-order release. SEM study showed pore formation on the tablet surface that differed depending on drug solubility. <italic>t</italic>-Test pointed to a significant difference in amount of both drugs released due to the difference in solubility. Solubility of the drug effects kinetics and the mechanism of drug release.</p></abstract>

The purpose of the present research work was to observe the effects of drug solubility on their release kinetics of water soluble verpamil hydrochloride and insoluble aceclofenac from hydrophilic polymer based matrix formulations. Matrix formulations were prepared by the direct compression method. The formulations were evaluated for various physical parameters. Along with the dynamics of water uptake and erosion, SEM and in vitro drug release of the tablets were studied. Applying an exponential equation, it was found that the kinetics of soluble drug release followed anomalous non-Fickian diffusion transport whereas insoluble drug showed zero-order release. SEM study showed pore formation on the tablet surface that differed depending on drug solubility. t-Test pointed to a significant difference in amount of both drugs released due to the difference in solubility. Solubility of the drug effects kinetics and the mechanism of drug release.

Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations

P.G. Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur-760002 Orissa, India

P.G. Department of Pharmaceutics, Gupta College of Pharmaceutical Sciences, Asansol, West Bengal, India

Acta Pharmaceutica

The purpose of the present research work was to observe the effects of drug solubility on their release kinetics of water soluble verpamil hydrochloride and...

Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations

Published Online: Oct 09, 2009

Page range: 313 - 323

DOI: https://doi.org/10.2478/v10007-009-0025-8

Keywords
topljivost, kinetika oslobađanja, bubrenje, erozija, matriksne tablete, statistička analiza

This content is open access.

Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations

Published Online: Oct 09, 2009

Page range: 313 - 323

DOI: https://doi.org/10.2478/v10007-009-0025-8

Keywordstopljivost, kinetika oslobađanja, bubrenje, erozija, matriksne tablete, statistička analiza

This content is open access.

Keywords
topljivost, kinetika oslobađanja, bubrenje, erozija, matriksne tablete, statistička analiza