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Synthesis of novel 1,3,4-oxadiazole derivatives and their biological properties

F. A. Omar, N. M. Mahfouz and M. A. Rahman, Design, synthesis and anti-inflammatory activity of some 1,3,4-oxadiazole derivatives, Eur. J. Med. Chem. 31 (1996) 819--825; DOI: 10.1016/0223-5234(96)83976-6.10.1016/0223-5234(96)83976-6Search in Google Scholar

B. Narayana, K. K. Vijayaraj, B. V. Ashlatha and N. S. Kumari, Synthesis of some new 2-(6-methoxy-2-naphthyl)-5-aryl-1,3,4-oxadiazoles as possible non-steroidal anti-inflammatory and analgesic agents, Arch. Pharm. (Weinheim) 338 (2005) 373--377; DOI: 10.1002/ardp.200400964.10.1002/ardp.200400964Search in Google Scholar

M. Amir and S. Kumar, Synthesis and evaluation of anti-inflammatory, analgesic and lipid peroxidation properties of ibuprofen derivatives, Acta Pharm. 57 (2007) 31--45; DOI: 10.2478/v10007-007-0003-y.10.2478/v10007-007-0003-ySearch in Google Scholar

S. L. Gaonkar, K. M. Rai and B. Prabhuswamy, Synthesis and antimicrobial studies of a new series of 2-{4-[2-(5-ethylpyridin-2-yl)ethoxy] phenyl}-5-substituted-1,3,4-oxadiazoles, Eur. J. Med. Chem. 41 (2006) 841--846; DOI: 10.1002/chin.200651110.10.1002/chin.200651110Search in Google Scholar

M. A. Ali and M. S. Yar, Oxadiazole Mannich bases: Synthesis and antimycobacterial activity, Bioorg. Med. Chem. Lett. 17 (2007) 3314--3316; DOI: 10.1016/j.bmcl.2007.04.004.10.1016/j.bmcl.2007.04.004Search in Google Scholar

A. Zarghi, S. A. Tabatabai, M. Faizi, A. Ahadian, P. Navabi, V. Zanganeh and A. Shafiee, Synthesis and anticonvulsant activity of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazole, Bioorg. Med. Chem. Lett. 15 (2005) 1863--1865; DOI: 10.1016/j.bmcl.2005.02.014.10.1016/j.bmcl.2005.02.014Search in Google Scholar

T. M. Tan, Y. Chen, K. H. Kong, J. Bai, Y. Li, S. G. Lim, T. H. Ang and Y. Lam, Synthesis and the biological evaluation of 2-benzenesulfonylalkyl-5-substituted-sulfanyl-(1,3,4)-oxadiazoles as potential anti-hepatitis B virus agents, Antiviral Res. 71 (2006) 7--14; DOI: 10.1016/j.antiviral.2006.02.007.10.1016/j.antiviral.2006.02.007Search in Google Scholar

F. L. Lanza, A guideline for the treatment and prevention of NSAID-induced ulcers, Am. J. Gastroenterol. 93 (1998) 2037--2046; DOI: 10.1016/S0002-9270(98)00469-9.10.1016/S0002-9270(98)00469-9Search in Google Scholar

F. Buttgereit, G. Burmester and L. S. Simon, Gastrointestestinal toxic side effects of non-steroidal anti-inflammatory drugs and cyclooxygenase-2-specific inhibitors, Am. J. Med. 110 (2001) 135--195; DOI: 10.10116/S0002-9343(00)00728-2.Search in Google Scholar

K. A. Metwally, S. H. Yaseen, E. M. Lashine, H. M. El-Fayomi and M. E. El-Sadek, Non-carboxylic analogues of aroylpropionic acids: Synthesis, anti-inflammatory activity and ulcerogenic potential, Eur. J. Med. Chem. 42 (2007) 152--160.Search in Google Scholar

V. Cioli, S. Putzolu, V. Rossi, P. S. Barcellona and C. Corradino, The role of direct tissue contact in the production of gastrointestinal ulcers by anti-inflammatory drugs in rats, Toxicol. Appl. Pharmacol. 50 (1979) 283--289; DOI: 10.1016/0041-008X(79)90153-4.10.1016/0041-008X(79)90153-4Search in Google Scholar

A. Husain, M. S. Y. Khan, S. M. Hasan and M. M. Alam, 2-Arylidene-4-(4-phenoxy-phenyl)but-3-en-4-olides: Synthesis, reactions and biological activity, Eur. J. Med. Chem. 40 (2005) 1394--1404; DOI: 10.1002/chin.200617109.10.1002/chin.200617109Search in Google Scholar

M. S. Y. Khan and A. Husain, Syntheses and reactions of some new 2-arylidene-4-(biphenyl-4-yl)but-3-en-4-olides with a study of their biological activity, Pharmazie 57 (2002) 448--452.Search in Google Scholar

N. Siddiqui, M. S. Alam and W. Ahsan, Synthesis, anticonvulsant and toxicity evaluation of 2-(1H-indol-3-yl)acetyl-N-(substituted phenyl)hydrazine carbothioamides and their related heterocyclic derivatives, Acta Pharm. 58 (2008) 445--454; DOI: 10.2478/v10007-008-0025-0.10.2478/v10007-008-0025-019103578Search in Google Scholar

C. A. Winter, E. A. Risley and G. W. Nuss, Carrageenin-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs, Proc. Soc. Exp. Biol. 111 (1962) 544--547.Search in Google Scholar

H. O. Collier, L. C. Dinneen, C. A. Johnson and C. Schneider, The abdominal constriction response and its suppression by analgesic drugs in the mouse, Br. J. Pharmacol. 32 (1968) 295--310.Search in Google Scholar

R. Cruickshank, J. P. Dugid, D. P. Marmion and R. H. A. Swain, Medical Microbiology, Vol. 2, Churchill, London 1975.Search in Google Scholar

eISSN:
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