<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>The current study involves development of oral bioadhesive hydrophilic matrices of hydralazine hydrochloride, and optimization of their <italic>in vitro</italic> drug release profile and <italic>ex vivo</italic> bioadhesion against porcine gastric mucosa. A 3<sup>2</sup> central composite design was employed to systematically optimize the drug delivery formulations containing two polymers, <italic>viz.</italic>, carbomer and hydroxypropyl methyl cellulose. Response surface plots were drawn and optimum formulations were selected by brute force searches. Validation of the formulation optimization study indicated a very high degree of prognostic ability. The study successfully undertook the development of an optimized once-a-day formulation of hydralazine with excellent bioadhesive and controlled release characteristics.</p></abstract>

The current study involves development of oral bioadhesive hydrophilic matrices of hydralazine hydrochloride, and optimization of their in vitro drug release profile and ex vivo bioadhesion against porcine gastric mucosa. A 32 central composite design was employed to systematically optimize the drug delivery formulations containing two polymers, viz., carbomer and hydroxypropyl methyl cellulose. Response surface plots were drawn and optimum formulations were selected by brute force searches. Validation of the formulation optimization study indicated a very high degree of prognostic ability. The study successfully undertook the development of an optimized once-a-day formulation of hydralazine with excellent bioadhesive and controlled release characteristics.

Formulation development of oral controlled release tablets of hydralazine: Optimization of drug release and bioadhesive characteristics

University Institute of Pharmaceutical Sciences (UGC Centre for Advanced Studies), Panjab University, Chandigarh-160014, India

Acta Pharmaceutica

The current study involves development of oral bioadhesive hydrophilic matrices of hydralazine hydrochloride, and optimization of their in vitro drug release...

Formulation development of oral controlled release tablets of hydralazine: Optimization of drug release and bioadhesive characteristics

Published Online: Mar 20, 2009

Page range: 1 - 13

DOI: https://doi.org/10.2478/v10007-009-0005-z

Keywords
hidralazin, dizajniranje eksperimenta, bioadhesivnost, metoda površina, gastrointestinalni terapijski sustav, hidrofilni matriksi

This content is open access.

Formulation development of oral controlled release tablets of hydralazine: Optimization of drug release and bioadhesive characteristics

Published Online: Mar 20, 2009

Page range: 1 - 13

DOI: https://doi.org/10.2478/v10007-009-0005-z

Keywordshidralazin, dizajniranje eksperimenta, bioadhesivnost, metoda površina, gastrointestinalni terapijski sustav, hidrofilni matriksi

This content is open access.

Keywords
hidralazin, dizajniranje eksperimenta, bioadhesivnost, metoda površina, gastrointestinalni terapijski sustav, hidrofilni matriksi