1. bookVolume 58 (2008): Issue 3 (September 2008)
Journal Details
License
Format
Journal
eISSN
1846-9558
ISSN
1330-0075
First Published
28 Feb 2007
Publication timeframe
4 times per year
Languages
English
access type Open Access

A study of rivastigmine liposomes for delivery into the brain through intranasal route

Journal Details
License
Format
Journal
eISSN
1846-9558
ISSN
1330-0075
First Published
28 Feb 2007
Publication timeframe
4 times per year
Languages
English
A study of rivastigmine liposomes for delivery into the brain through intranasal route

The present study is mainly aimed at delivering a drug into the brain via the intranasal route using a liposomal formulation. For this purpose, rivastigmine, which is used in the management of Alzheimer's disease, was selected as a model drug. Conventional liposomes were formulated by the lipid layer hydration method using cholesterol and soya lecithin as lipid components. The concentration of rivastigmine in brain and plasma after intranasal liposomes, free drug and per oral administration was studied in rat models. A significantly higher level of drug was found in the brain with intranasal liposomes of rivastigmine compared to the intranasal free drug and the oral route. Intranasal liposomes had a longer half-life in the brain than intranasally or orally administered free drug. Delivering rivastigmine liposomes through the intranasal route for the treatment of Alzheimer's disease might be a new approach to the management of this condition.

Keywords

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