<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml">A gastro retentive controlled release system of loratadine was formulated to increase the residence time in stomach and to modulate the release behaviour of the drug. Oil entrapped floating microbeads prepared by the emulsion gelation method were optimized by 23 factorial design and a polymer ratio of 2.5:1.5 (pectin/sodium alginate) by mass, 15% (<italic>m/V</italic>) of oil (mineral oil or castor oil) and 0.45 mol L-1 calcium chloride solution as the optimized processing conditions for the desired buoyancy and physical stability. <italic>In vitro</italic> drug release in the fed state conditions demonstrated sustained release of loratadine for 8 h, which best fitted the Peppas model with <italic>n</italic> &lt; 0.45. The ethyl cellulose coating on microbeads optimized by 22 factorial design resulted in a controlled release formulation of loratadine that provided zero-order release for 8 h.</abstract>

A gastro retentive controlled release system of loratadine was formulated to increase the residence time in stomach and to modulate the release behaviour of the drug. Oil entrapped floating microbeads prepared by the emulsion gelation method were optimized by 23 factorial design and a polymer ratio of 2.5:1.5 (pectin/sodium alginate) by mass, 15% (m/V) of oil (mineral oil or castor oil) and 0.45 mol L-1 calcium chloride solution as the optimized processing conditions for the desired buoyancy and physical stability. In vitro drug release in the fed state conditions demonstrated sustained release of loratadine for 8 h, which best fitted the Peppas model with n < 0.45. The ethyl cellulose coating on microbeads optimized by 22 factorial design resulted in a controlled release formulation of loratadine that provided zero-order release for 8 h.

Formulation and evaluation of oil entrapped gastroretentive floating gel beads of loratadine

Advanced Institute of Biotechnology and Paramedical Sciences, Kanpur, India

Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura-281001, India

Acta Pharmaceutica

A gastro retentive controlled release system of loratadine was formulated to increase the residence time in stomach and to modulate the release behaviour of...

Formulation and evaluation of oil entrapped gastroretentive floating gel beads of loratadine

Published Online: May 30, 2008

Page range: 187 - 197

DOI: https://doi.org/10.2478/v10007-008-0001-8

Keywords
loratadin, zadržavanje u želucu, faktorijalni dizajn, presvlaka od etilceluloze, kinetika nultog reda

This content is open access.

Formulation and evaluation of oil entrapped gastroretentive floating gel beads of loratadine

Published Online: May 30, 2008

Page range: 187 - 197

DOI: https://doi.org/10.2478/v10007-008-0001-8

Keywordsloratadin, zadržavanje u želucu, faktorijalni dizajn, presvlaka od etilceluloze, kinetika nultog reda

This content is open access.

Keywords
loratadin, zadržavanje u želucu, faktorijalni dizajn, presvlaka od etilceluloze, kinetika nultog reda