<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>The purpose of this study was to improve the entrapment efficiency of the water-soluble drug metronidazole using internal cross-linking agents. Calcium pectinate beads containing metronidazole were prepared by dropping a drug-pectin solution in 1% and 5% (<italic>m/V</italic>) calcium chloride for surface cross-linked beads. For the core cross-linked beads calcium carbonate was dispersed in the drug-pectin solution. The beads were characterized by particle size, swelling ratio, SEM, DSC, and <italic>in vitro</italic> drug release. It was found that the beads obtained by core cross-linking produced more drug entrapped beads than the surface cross-linked beads. Beads obtained using 1% (<italic>m/V</italic>) calcium chloride showed more drug entrapment than these obtained using 5% calcium chloride. The core cross-linking of pectin beads reduced drug loss by about 10--20%. The water lodging capacity of beads depended upon gel strength which is a function of the internal gelling agent and pectin concentration. Complete drug release was observed within 30--60 min in the acidic dissolution medium. This work has showed that the core cross-linking agent increases the water-soluble drug entrapment in calcium pectinate beads.</p></abstract>

The purpose of this study was to improve the entrapment efficiency of the water-soluble drug metronidazole using internal cross-linking agents. Calcium pectinate beads containing metronidazole were prepared by dropping a drug-pectin solution in 1% and 5% (m/V) calcium chloride for surface cross-linked beads. For the core cross-linked beads calcium carbonate was dispersed in the drug-pectin solution. The beads were characterized by particle size, swelling ratio, SEM, DSC, and in vitro drug release. It was found that the beads obtained by core cross-linking produced more drug entrapped beads than the surface cross-linked beads. Beads obtained using 1% (m/V) calcium chloride showed more drug entrapment than these obtained using 5% calcium chloride. The core cross-linking of pectin beads reduced drug loss by about 10--20%. The water lodging capacity of beads depended upon gel strength which is a function of the internal gelling agent and pectin concentration. Complete drug release was observed within 30--60 min in the acidic dissolution medium. This work has showed that the core cross-linking agent increases the water-soluble drug entrapment in calcium pectinate beads.

Effect of core and surface cross-linking on the entrapment of metronidazole in pectin beads

Department of Pharmaceutics Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune-411038, India

Acta Pharmaceutica

The purpose of this study was to improve the entrapment efficiency of the water-soluble drug metronidazole using internal cross-linking agents. Calcium...

Effect of core and surface cross-linking on the entrapment of metronidazole in pectin beads

Published Online: Mar 12, 2008

Page range: 78 - 85

DOI: https://doi.org/10.2478/v10007-007-0046-0

Keywords
ionotropsko geliranje, sredstvo za umrežavanje jezgre, kalcijev karbonat, udio lijeka, metronidazol, zrnca Ca-pektinata

This content is open access.

Effect of core and surface cross-linking on the entrapment of metronidazole in pectin beads

Published Online: Mar 12, 2008

Page range: 78 - 85

DOI: https://doi.org/10.2478/v10007-007-0046-0

Keywordsionotropsko geliranje, sredstvo za umrežavanje jezgre, kalcijev karbonat, udio lijeka, metronidazol, zrnca Ca-pektinata

This content is open access.

Keywords
ionotropsko geliranje, sredstvo za umrežavanje jezgre, kalcijev karbonat, udio lijeka, metronidazol, zrnca Ca-pektinata