Gene Expression Profiling in Bone Tissue of Osteoporotic Mice

Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet 2002;359:1761-7.10.1016/S0140-6736(02)08657-9Search in Google Scholar

Hui SL, Slemenda CW, Johnston CC. Baseline measurement of bone mass predicts fracture in white women. Ann Intern Med 1989;111:355-61.10.7326/0003-4819-111-5-3552764403Search in Google Scholar

Raisz LG. Physiology and pathophysiology of bone remodeling. Clin Chem 1999;45:1353-8.Search in Google Scholar

Dvornyk V, Recker RR, Deng HW. Gene expression studies of osteoporosis: implications for microarray research. Osteoporos Int 2003;146:451-61.10.1007/s00198-002-1373-012730742Search in Google Scholar

Ralston SH. Analysis of gene expression in human bone biopsies by polymerase chain reaction: evidence for enhanced cytokine expression in postmenopausal osteoporosis. J Bone Miner Res. 1994;96:883-90.10.1002/jbmr.56500906148079663Search in Google Scholar

Liu YZ, Dvornyk V, Lu Y, Shen H, Lappe JM, Recker RR, Deng HW. A novel pathophysiological mechanism for osteoporosis suggested by an in vivo gene expression study of circulating monocytes. J Biol Chem 2005;280:29011-6.10.1074/jbc.M50116420015965235Search in Google Scholar

Pacifici R, Rifas L, Teitelbaum S, Slatopolsky E, McCracken R, Bergfeld M, Lee W, Avioli LV, Peck WA. Spontaneous release of interleukin 1 from human blood monocytes reflects bone formation in idiopathic osteoporosis. Proc Natl Acad Sci USA 1987;84:4616-20.10.1073/pnas.84.13.46163051413496597Search in Google Scholar

Pacifici R, Brown C, Puscheck E, Friedrich E, Slatopolsky E, Maggio D, McCracken R, Avioli LV. Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells. Proc Natl Acad Sci USA 1991;88:5134-8.10.1073/pnas.88.12.5134518262052592Search in Google Scholar

Kimmel DB. Animal models in osteoporosis research. In: Bilezikian JP, Raisz LG, Rodan GA, editors. Principles of Bone Biology. 2^nd ed. San Diego, San Francisco, New York, Boston, London, Sydeny, Tokyo: Academic Press; 2002. p. 1635-55.Search in Google Scholar

Helvering LM, Liu R, Kulkarni NH, Wei T, Chen P, Huang S, Lawrence F, Halladay DL, Miles RR, Ambrose EM, Sato M, Ma YL, Frolik CA, Dow ER, Bryant HU, Onyia JE. Expression profiling of rat femur revealed suppression of bone formation genes by treatment with alendronate and estrogen but not raloxifene. Mol Pharmacol 2005;685:1225-38.10.1124/mol.105.01147816079270Search in Google Scholar

Simic P, Buljan-Culej J, Orlic I, Borovecki F, Vukicevic S. BMP-6 restores bone in osteoporotic aged rats and, unlike estradiol and PTH, restores trabecular bone in ovariectomized BMP-6 knockout mice. J Bone Miner Res 2005;20:S8.Search in Google Scholar

Borovecki F, Grasser WA, Orlic I, Paralkar VM, Vukicevic S. BMP-6 induces new bone formation in ovariectomized mice and enhances differentiation of primary human osteoblasts through activation of IGF-1 and EGF pathways. Calcif Tissue Int 2006;78:S71-2.Search in Google Scholar

National Academy of Sciences, Institute of Laboratory Animal Resources Commission on Life Sciences. Guide for the Care and Use of Laboratory Animals [displayed 15^th December 2006]. Available at http://www.nap.edu/readingroom/books/labratsSearch in Google Scholar

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 2005;102:15545-50.10.1073/pnas.0506580102123989616199517Search in Google Scholar

Turner RT, Riggs BL, and Spelsberg TC. Skeletal effects of estrogen. Endocrine Rev 1994;15:275-300.Search in Google Scholar

Miyaura C, Onoe Y, Inada M, Maki K, Ikuta K, Ito M, Suda T. Increased B-lymphopoiesis by interleukin 7 induces bone loss in mice with intact ovarian function: similarity to estrogen deficiency. Proc Natl Acad Sci USA 1997;94:9360-5.10.1073/pnas.94.17.9360231939256487Search in Google Scholar

Hofmeister R, Khaled AR, Benbernou N, Rajnavolgyi E, Muegge K, Durum SK. Interleukin-7: physiological roles and mechanisms of action. Cytokine Growth Factor Rev 1999;10:41-60.10.1016/S1359-6101(98)00025-2Search in Google Scholar

Xiao Y, Fu H, Prasadam I, Yang YC, Hollinger JO. Gene expression profiling of bone marrow stromal cells from juvenile, adult, aged and osteoporotic rats: With an emphasis on osteoporosis. Bone. 2006;40(3):700-15.10.1016/j.bone.2006.10.02117166785Search in Google Scholar

Van Lint P, Libert C. Matrix metalloproteinase-8: cleavage can be decisive. Cytokine Growth Factor Rev 2006;17:217-23.10.1016/j.cytogfr.2006.04.00116820317Search in Google Scholar

Weitzmann MN, Pacifici R. Estrogen deficiency and bone loss: an inflammatory tale. J Clin Invest 2006;116:1186-94.10.1172/JCI28550145121816670759Search in Google Scholar

Roggia C, Gao Y, Cenci S, Weitzmann MN, Toraldo G, Isaia G, Pacifici R. Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo.Proc Natl Acad Sci USA 2001;98:13960-5.10.1073/pnas.2515346986114911717453Search in Google Scholar

Kim MS, Magno CL, Day CJ, Morrison NA. Induction of chemokines and chemokine receptors CCR2b and CCR4 in authentic human osteoclasts differentiated with RANKL and osteoclast like cells differentiated by MCP-1 and RANTES. J Cell Biochem 2006;973:512-8.10.1002/jcb.2064916211583Search in Google Scholar

Weitzmann MN, Roggia C, Toraldo G, Weitzmann L, Pacifici R. Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency. J Clin Invest 2002;110:1643-50.10.1172/JCI0215687Search in Google Scholar

Finkelman RD, Bell NH, Strong DD, Demers LM, Baylink DJ. Ovariectomy selectively reduces the concentration of transforming growth factor beta in rat bone: implications for estrogen deficiency-associated bone loss. Proc Natl Acad Sci USA 1992;89:12190-3.10.1073/pnas.89.24.12190507241465458Search in Google Scholar

Yang NN, Bryant HU, Hardikar S, Sato M, Galvin RJ, Glasebrook AL, Termine JD. Estrogen and raloxifene stimulate transforming growth factor-beta 3 gene expression in rat bone: a potential mechanism for estrogen- or raloxifene-mediated bone maintenance. Endocrinology 1996;137:2075-84.10.1210/endo.137.5.86125508612550Search in Google Scholar

Potts JT. Parathyroid hormone: past and present. J Endocrinol 2005;183:311-25.10.1677/joe.1.0605716423810Search in Google Scholar

Gori F, Friedman LG, Demay MB. Wdr5, a WD-40 protein, regulates osteoblast differentiation during embryonic bone development. Dev Biol 2006;295:498-506.10.1016/j.ydbio.2006.02.03116730692Search in Google Scholar