<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Prostate cancer is a worldwide health concern with an increasing global incidence. In the Republic of Serbia, it is the third most commonly diagnosed cancer in men. The research aims to determine the influence of PSA value and digital rectal examination on the pathohistological findings of prostate biopsy in men in Central Serbia. The study was designed as a retrospective, cross-sectional analytical study conducted in the period from December 2021 to December 2022 after receiving the confirmation of the Ethics Committee of the University of Applied Sciences Kragujevac. Among 151 respondents aged 49 to 88 who underwent consecutive biopsies during the study period, prostate cancer was detected in 65 (42%). Out of 65 positive biopsies, 33 subjects had a Gleason score of up to 7, while 32 subjects had a Gleason score over 7. Prostate biopsies significantly correlated with PSA levels (p=0.02), while DRE and prostate volume did not show statistical significance on the prostate biopsy result. PSA level testing leads to early detection of prostate disease in the elderly. PSA value was the only clinical variable associated with an increased rate of prostate cancer in men ≥ 70 and older (p=0.02). DRE, PSA, and prostate volume are important parameters associated with an increase in prostate cancer detection rate in men over 70 years of age.</p>
</abstract>

Prostate cancer is a worldwide health concern with an increasing global incidence. In the Republic of Serbia, it is the third most commonly diagnosed cancer in men. The research aims to determine the influence of PSA value and digital rectal examination on the pathohistological findings of prostate biopsy in men in Central Serbia. The study was designed as a retrospective, cross-sectional analytical study conducted in the period from December 2021 to December 2022 after receiving the confirmation of the Ethics Committee of the University of Applied Sciences Kragujevac. Among 151 respondents aged 49 to 88 who underwent consecutive biopsies during the study period, prostate cancer was detected in 65 (42%). Out of 65 positive biopsies, 33 subjects had a Gleason score of up to 7, while 32 subjects had a Gleason score over 7. Prostate biopsies significantly correlated with PSA levels (p=0.02), while DRE and prostate volume did not show statistical significance on the prostate biopsy result. PSA level testing leads to early detection of prostate disease in the elderly. PSA value was the only clinical variable associated with an increased rate of prostate cancer in men ≥ 70 and older (p=0.02). DRE, PSA, and prostate volume are important parameters associated with an increase in prostate cancer detection rate in men over 70 years of age.

Prognostic Value of Prostata Specific Antigen and Digital Rectal Examination at Prostate Biopsy

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Prostate cancer is a worldwide health concern with an increasing global incidence. In the Republic of Serbia, it is the third most commonly diagnosed cancer in...

Prognostic Value of Prostata Specific Antigen and Digital Rectal Examination at Prostate Biopsy

Published Online: Jan 24, 2024

Page range: -

Received: Apr 05, 2023

Accepted: Nov 20, 2023

DOI: https://doi.org/10.2478/sjecr-2023-0011

Keywords
Older patients, PSA screening, pathohistological findings, digital rectal examination, prostate biopsy

© 2023 Filip Milutinovic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Prognostic Value of Prostata Specific Antigen and Digital Rectal Examination at Prostate Biopsy

Published Online: Jan 24, 2024

Page range: -

Received: Apr 05, 2023

Accepted: Nov 20, 2023

DOI: https://doi.org/10.2478/sjecr-2023-0011

KeywordsOlder patients, PSA screening, pathohistological findings, digital rectal examination, prostate biopsy

© 2023 Filip Milutinovic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
Older patients, PSA screening, pathohistological findings, digital rectal examination, prostate biopsy