<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Measuring the concentration of antibiotics in biological samples allow implementation of therapeutic monitoring of these drugs and contribute to the adjustment of the dosing regimen in patients. This increases the effectiveness of antimicrobial therapy, reduces the toxicity of these drugs and prevents the development of bacterial resistance. This review article summarizes current knowledge on methods for determining concentration of meropenem, an antibiotic drug from the group of carbapenems, in different biological samples. It provides a brief discussion of the chemical structure, physicochemical and pharmacokinetic properties of meropenem, different sample preparation techniques, use of apparatus and equipment, knowledge of the advantages and limitations of available methods, as well as directions in which new methods should be developed. This review should facilitate clinical laboratories to select and apply one of the established methods for measuring of meropenem, as well as to provide them with the necessary knowledge to develop new methods for quantification of meropenem in biological samples according to their needs.</p>
</abstract>

Measuring the concentration of antibiotics in biological samples allow implementation of therapeutic monitoring of these drugs and contribute to the adjustment of the dosing regimen in patients. This increases the effectiveness of antimicrobial therapy, reduces the toxicity of these drugs and prevents the development of bacterial resistance. This review article summarizes current knowledge on methods for determining concentration of meropenem, an antibiotic drug from the group of carbapenems, in different biological samples. It provides a brief discussion of the chemical structure, physicochemical and pharmacokinetic properties of meropenem, different sample preparation techniques, use of apparatus and equipment, knowledge of the advantages and limitations of available methods, as well as directions in which new methods should be developed. This review should facilitate clinical laboratories to select and apply one of the established methods for measuring of meropenem, as well as to provide them with the necessary knowledge to develop new methods for quantification of meropenem in biological samples according to their needs.

Methods for Determination of Meropenem Concentration in Biological Samples

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Methods for Determination of Meropenem Concentration in Biological Samples"}

Measuring the concentration of antibiotics in biological samples allow implementation of therapeutic monitoring of these drugs and contribute to the adjustment...

Methods for Determination of Meropenem Concentration in Biological Samples

Published Online: Apr 11, 2022

Page range: -

Received: Nov 08, 2021

Accepted: Jan 26, 2022

DOI: https://doi.org/10.2478/sjecr-2022-0005

Keywords
meropenem, methods for determination, chromatographic methods, biological samples, therapeutic drug monitoring

© 2022 Aleksandar Rancic, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Methods for Determination of Meropenem Concentration in Biological Samples

Published Online: Apr 11, 2022

Page range: -

Received: Nov 08, 2021

Accepted: Jan 26, 2022

DOI: https://doi.org/10.2478/sjecr-2022-0005

Keywordsmeropenem, methods for determination, chromatographic methods, biological samples, therapeutic drug monitoring

© 2022 Aleksandar Rancic, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
meropenem, methods for determination, chromatographic methods, biological samples, therapeutic drug monitoring