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<p>Hemocorrectors based on perfluorocarbon gas-transport blood-substituting emulsions are complex multiphase systems used in the biomedical field as multifunctional drugs, in particular, as gas-transport substitutes for a blood donor. The aim of this review was to discuss their physicochemical and medico-biological properties. A number of preparations from both Russian and foreign manufacturers based on chemically inert perfluorocarbon blood-substituting emulsions of a nano-size level as hemocorrectors with a gas transport function are shown. The analysis of the effect of perfluorocarbon emulsion on the blood gas transport indicators showed that perfluorocarbon particles in the bloodstream will significantly improve the conditions of gas exchange in tissues. The most important issue is the concentration of perfluorocarbon blood-substituting emulsions. The perfluorocarbon emulsions can be considered as a means of correcting the gas transport properties of blood, increasing the reserve capacity of blood cells-red blood cells to deliver oxygen to the tissues. Taking into account all facts about perfluorocarbon hemocorrectors, it can be concluded that they can be used as universal nanocarriers for the transdermal delivery of oxygen and biologically active compounds in various fields of biomedicine and cosmetology.</p>
</abstract>

Hemocorrectors based on perfluorocarbon gas-transport blood-substituting emulsions are complex multiphase systems used in the biomedical field as multifunctional drugs, in particular, as gas-transport substitutes for a blood donor. The aim of this review was to discuss their physicochemical and medico-biological properties. A number of preparations from both Russian and foreign manufacturers based on chemically inert perfluorocarbon blood-substituting emulsions of a nano-size level as hemocorrectors with a gas transport function are shown. The analysis of the effect of perfluorocarbon emulsion on the blood gas transport indicators showed that perfluorocarbon particles in the bloodstream will significantly improve the conditions of gas exchange in tissues. The most important issue is the concentration of perfluorocarbon blood-substituting emulsions. The perfluorocarbon emulsions can be considered as a means of correcting the gas transport properties of blood, increasing the reserve capacity of blood cells-red blood cells to deliver oxygen to the tissues. Taking into account all facts about perfluorocarbon hemocorrectors, it can be concluded that they can be used as universal nanocarriers for the transdermal delivery of oxygen and biologically active compounds in various fields of biomedicine and cosmetology.

Hemocorrectors Based on Perfluorocarbon Gas-Transport Blood-Substituting Emulsions

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Hemocorrectors based on perfluorocarbon gas-transport blood-substituting emulsions are complex multiphase systems used in the biomedical field as...

Hemocorrectors Based on Perfluorocarbon Gas-Transport Blood-Substituting Emulsions

Published Online: Aug 05, 2021

Page range: 95 - 100

Received: May 24, 2021

Accepted: Jun 04, 2021

DOI: https://doi.org/10.2478/sjecr-2021-0031

Keywords
hemocorrectors, perfluorocarbon gas-transport blood-substituting emulsions, biological characteristic, medical characteristic

© 2021 Sergei I. Vorobyev et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Hemocorrectors Based on Perfluorocarbon Gas-Transport Blood-Substituting Emulsions

Published Online: Aug 05, 2021

Page range: 95 - 100

Received: May 24, 2021

Accepted: Jun 04, 2021

DOI: https://doi.org/10.2478/sjecr-2021-0031

Keywordshemocorrectors, perfluorocarbon gas-transport blood-substituting emulsions, biological characteristic, medical characteristic

© 2021 Sergei I. Vorobyev et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
hemocorrectors, perfluorocarbon gas-transport blood-substituting emulsions, biological characteristic, medical characteristic