[
1. Volarevic V, Ljujic B, Stojkovic P, Lukic A, Arsenijevic N, Stojkovic M. Human stem cell research and regenerative medicine--present and future. Br Med Bull. 2011;99:155-68.10.1093/bmb/ldr02721669982
]Search in Google Scholar
[
2. Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8(4):315-7.10.1080/1465324060085590516923606
]Search in Google Scholar
[
3. Volarevic V, Nurkovic J, Arsenijevic N, Stojkovic M. Concise review: Therapeutic potential of mesenchymal stem cells for the treatment of acute liver failure and cirrhosis. Stem Cells. 2014;32(11):2818-23.10.1002/stem.181825154380
]Search in Google Scholar
[
4. Volarevic V, Al-Qahtani A, Arsenijevic N, Pajovic S, Lukic ML. Interleukin-1 receptor antagonist (IL-1Ra) and IL-1Ra producing mesenchymal stem cells as modulators of diabetogenesis. Autoimmunity. 2010;43(4):255-63.10.3109/0891693090330564119845478
]Search in Google Scholar
[
5. Djouad F, Charbonnier LM, Bouffi C, Louis-Plence P, et al. Mesenchymal stem cells inhibit the differentiation of dendritic cells through an interleukin-6-dependent mechanism. Stem Cells. 2007;25(8):2025-32.10.1634/stemcells.2006-054817510220
]Search in Google Scholar
[
6. Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood. 2005;105(4):1815-22.10.1182/blood-2004-04-155915494428
]Search in Google Scholar
[
7. Beyth S, Borovsky Z, Mevorach D, et al. Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood. 2005;105(5):2214-9.10.1182/blood-2004-07-292115514012
]Search in Google Scholar
[
8. Chamberlain G, Fox J, Ashton B, Middleton J. Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells. 2007;25(11):2739-49.10.1634/stemcells.2007-019717656645
]Search in Google Scholar
[
9. Gazdic M, Volarevic V, Arsenijevic N, Stojkovic M. Mesenchymal stem cells: a friend or foe in immune-mediated diseases. Stem Cell Rev Rep. 2015;11(2):280-7.10.1007/s12015-014-9583-325592610
]Search in Google Scholar
[
10. Waterman RS, Tomchuck SL, Henkle SL, Betancourt AM. A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype. PLoS One. 2010;5(4):e10088.10.1371/journal.pone.0010088285993020436665
]Search in Google Scholar
[
11. Shi Y, Wang Y, Li Q, et al. Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases. Nat Rev Nephrol. 2018;14(8):493-507.10.1038/s41581-018-0023-529895977
]Search in Google Scholar
[
12. Romieu-Mourez R, François M, Boivin MN, Bouchentouf M, Spaner DE, Galipeau J. Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype. J Immunol. 2009;182(12):7963-73.10.4049/jimmunol.080386419494321
]Search in Google Scholar
[
13. Ma S, Xie N, Li W, Yuan B, Shi Y, Wang Y. Immunobiology of mesenchymal stem cells. Cell Death Differ. 2014;21(2):216-25.10.1038/cdd.2013.158389095524185619
]Search in Google Scholar
[
14. Harrell CR, Jovicic N, Djonov V, Volarevic V. Therapeutic Use of Mesenchymal Stem Cell-Derived Exosomes: From Basic Science to Clinics. Pharmaceutics. 2020;12(5):474.10.3390/pharmaceutics12050474731371332456070
]Search in Google Scholar
[
15. Harrell CR, Miloradovic D, Sadikot R, et al. Molecular and Cellular Mechanisms Responsible for Beneficial Effects of Mesenchymal Stem Cell-Derived Product “Exod- MAPPS” in Attenuation of Chronic Airway Inflammation. Anal Cell Pathol (Amst). 2020;2020:3153891.
]Search in Google Scholar
[
16. Colombo M, Raposo G, Théry C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol. 2014;30:255-89.10.1146/annurev-cellbio-101512-12232625288114
]Search in Google Scholar
[
17. Ferreira JR, Teixeira GQ, Santos SG, Barbosa MA, Almeida- Porada G, Gonçalves RM. Mesenchymal Stromal Cell Secretome: Influencing Therapeutic Potential by Cellular Pre-conditioning. Front Immunol. 2018;9:2837.10.3389/fimmu.2018.02837628829230564236
]Search in Google Scholar
[
18. Kaur S, Abu-Shahba AG, Paananen RO, et al. Small non-coding RNA landscape of extracellular vesicles from human stem cells. Sci Rep. 2018;8(1):15503.10.1038/s41598-018-33899-6619556530341351
]Search in Google Scholar
[
19. Whiteside TL. Exosome and mesenchymal stem cell cross-talk in the tumor microenvironment. Semin Immunol. 2018;35:69-79.10.1016/j.smim.2017.12.003586620629289420
]Search in Google Scholar
[
20. Androulidaki A, Iliopoulos D, Arranz A, et al. The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity. 2009;31(2):220-231.10.1016/j.immuni.2009.06.024286558319699171
]Search in Google Scholar
[
21. Kumar M, Ahmad T, Sharma A, Mabalirajan U, Kulshreshtha A, Agrawal A, Ghosh B. Let-7 microRNA- mediated regulation of IL-13 and allergic airway inflammation. J Allergy Clin Immunol. 2011;128(5):1077-85.e1-10.10.1016/j.jaci.2011.04.03421616524
]Search in Google Scholar
[
22. Schulte LN, Eulalio A, Mollenkopf HJ, Reinhardt R, Vogel J. Analysis of the host microRNA response to Salmonella uncovers the control of major cytokines by the let-7 family. EMBO J. 2011;30(10):1977-89.10.1038/emboj.2011.94309849521468030
]Search in Google Scholar
[
23. Yang, L., Boldin, M. P., Yu, Y., Liu, C. S., Ea, C. K., Ramakrishnan, P., et al.. miR-146a controls the resolution of T cell responses in mice. Journal of Experimental Medicine. 2012; 209(9), 1655–1670.
]Search in Google Scholar
[
24. Hart, M., Walch-Rückheim, B., Friedmann, K, S., Rheinheimer, S., Tänzer, T., Glombitza, B., … Meese, E. miR-34a: A new player in the regulation of T cell function by modulation of NF-κB signaling. Cell Death and Disease. 2019;10(2):4610.1038/s41419-018-1295-1636200730718475
]Search in Google Scholar
[
25. Hillman, Y., Mazkereth, N., Farberov, L., Shomron, N., & Fishelson, Z. Regulation of complement-dependent cytotoxicity by MicroRNAs miR-200b, miR-200c, and miR-217. The Journal of Immunology. 2016;196(12), 5156–5165.
]Search in Google Scholar
[
26. Kehl D, Generali M, Mallone A, Heller M, Uldry AC, Cheng P, Gantenbein B, Hoerstrup SP, Weber B. Proteomic analysis of human mesenchymal stromal cell secretomes: a systematic comparison of the angiogenic potential. NPJ Regen Med. 2019;4:8.10.1038/s41536-019-0070-y646790431016031
]Search in Google Scholar
[
27. Kong P, Xie X, Li F, Liu Y, Lu Y. Placenta mesenchymal stem cell accelerates wound healing by enhancing angiogenesis in diabetic Goto-Kakizaki (GK) rats. Biochem Biophys Res Commun. 2013;438(2):410-9.10.1016/j.bbrc.2013.07.08823899518
]Search in Google Scholar
[
28. Bai L, Li D, Li J, et al. Bioactive molecules derived from umbilical cord mesenchymal stem cells. Acta Histochem. 2016;118(8):761-769.10.1016/j.acthis.2016.09.00627692875
]Search in Google Scholar
[
29. Tao H, Han Z, Han ZC, Li Z. Proangiogenic Features of Mesenchymal Stem Cells and Their Therapeutic Applications. Stem Cells Int. 2016; 1314709.10.1155/2016/1314709473681626880933
]Search in Google Scholar
[
30. Corliss BA, Azimi MS, Munson JM, Peirce SM, Murfee WL. Macrophages: An Inflammatory Link Between Angiogenesis and Lymphangiogenesis. Microcirculation. 2016;23(2):95-121.10.1111/micc.12259474413426614117
]Search in Google Scholar
[
31. Motegi SI, Ishikawa O. Mesenchymal stem cells: The roles and functions in cutaneous wound healing and tumor growth. J Dermatol Sci. 2017;86(2):83-89.10.1016/j.jdermsci.2016.11.00527866791
]Search in Google Scholar
[
32. Harrell CR, Fellabaum C, Jovicic N, Djonov V, Arsenijevic N, Volarevic V. Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome. Cells. 2019;8(5):467.10.3390/cells8050467656290631100966
]Search in Google Scholar
[
33. Stenderup, K., Justesen, J., Clausen, C., and Kassem, M. Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. Bone. 2003; 33, 919–926.
]Search in Google Scholar
[
34. Lu LL, Liu YJ, Yang SG, et al. Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials. Haematologica. 2006;91(8):1017-26.
]Search in Google Scholar
[
35. Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 2002;13(12):4279-95.10.1091/mbc.e02-02-010513863312475952
]Search in Google Scholar
[
36. Jin HJ, Bae YK, Kim M, et al. Comparative analysis of human mesenchymal stem cells from bone marrow, adipose tissue, and umbilical cord blood as sources of cell therapy. Int J Mol Sci. 2013;14(9):17986-8001.10.3390/ijms140917986379476424005862
]Search in Google Scholar
[
37. Kern S, Eichler H, Stoeve J, Klüter H, Bieback K. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells. 2006; 24(5):1294-301.10.1634/stemcells.2005-034216410387
]Search in Google Scholar
[
38. Markovic BS, Kanjevac T, Harrell CR, et al. Molecular and Cellular Mechanisms Involved in Mesenchymal Stem Cell-Based Therapy of Inflammatory Bowel Diseases. Stem Cell Rev. 2018;14(2):153-16510.1007/s12015-017-9789-229177796
]Search in Google Scholar
[
39. Harrell CR, Gazdic M, Fellabaum C, et al. Therapeutic Potential of Amniotic Fluid Derived Mesenchymal Stem Cells Based on their Differentiation Capacity and Immunomodulatory Properties. Curr Stem Cell Res Ther. 2019; 14: 327-336.10.2174/1574888X1466619022220174930806325
]Search in Google Scholar
[
40. Chamberlain G, Fox J, Ashton B, Middleton J. Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells. 2007;25(11):2739-2749.10.1634/stemcells.2007-019717656645
]Search in Google Scholar
[
41. Xie XH, Wang XL, He YX, et al. Promotion of bone repair by implantation of cryopreserved bone marrow-derived mononuclear cells in a rabbit model of steroid-associated osteonecrosis. Arthritis Rheum. 2012;64(5):1562-1571.10.1002/art.3452522544527
]Search in Google Scholar
[
42. Mueller SM, Glowacki J. Age-related decline in the osteogenic potential of human bone marrow cells cultured in three-dimensional collagen sponges. J Cell Biochem. 2001;82(4):583-590.10.1002/jcb.117411500936
]Search in Google Scholar
[
43. Stenderup K, Justesen J, Clausen C, Kassem M. Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. Bone. 2003;33(6):919-92610.1016/j.bone.2003.07.00514678851
]Search in Google Scholar
[
44. Lu LL, Liu YJ, Yang SG, et al. Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials. Haematologica. 2006;91(8):1017-1026
]Search in Google Scholar
[
45. Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 2002;13(12):4279-4295.10.1091/mbc.e02-02-010513863312475952
]Search in Google Scholar
[
46. Desterke C, Griscelli F, Imeri J, et al. Molecular investigation of adequate sources of mesenchymal stem cells for cell therapy of COVID-19-associated organ failure. Stem Cells Transl Med. 2020; 25:10.1002/sctm.20-0189.10.1002/sctm.20-0189775375333237619
]Search in Google Scholar
[
47. Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270-273.10.1038/s41586-020-2012-7
]Search in Google Scholar
[
48. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506.10.1016/S0140-6736(20)30183-5
]Search in Google Scholar
[
49. Li Q, Guan X, Wu P, et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med. 2020;382(13):1199-1207.10.1056/NEJMoa2001316712148431995857
]Search in Google Scholar
[
50. Rajarshi K, Chatterjee A, Ray S. Combating COVID-19 with mesenchymal stem cell therapy. Biotechnol Rep (Amst). 2020;26:e00467.10.1016/j.btre.2020.e00467722467132420049
]Search in Google Scholar
[
51. Wang J, Jiang M, Chen X, Montaner LJ. Cytokine storm and leukocyte changes in mild versus severe SARSCoV- 2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts. J Leukoc Biol. 2020;108(1):17-41.10.1002/JLB.3COVR0520-272R732325032534467
]Search in Google Scholar
[
52. Gupta KK, Khan MA, Singh SK. Constitutive Inflammatory Cytokine Storm: A Major Threat to Human Health. J Interferon Cytokine Res. 2020;40(1):19-23.10.1089/jir.2019.008531755797
]Search in Google Scholar
[
53. Hu B, Huang S, Yin L. The cytokine storm and COVID-19. J Med Virol. 2021;93(1):250-256.10.1002/jmv.26232736134232592501
]Search in Google Scholar
[
54. Hussman JP. Cellular and Molecular Pathways of COVID-19 and Potential Points of Therapeutic Intervention. Front Pharmacol. 2020;11:1169.10.3389/fphar.2020.01169740691632848776
]Search in Google Scholar
[
55. Zhou Y, Fu B, Zheng X, et al. Aberrant pathogenic GMCSF+ T cells and inflammatory CD14+CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus. bioRxiv. 2020;10.1101/2020.02.12.945576
]Search in Google Scholar
[
56. Eguchi S, Kawai T, Scalia R, Rizzo V. Understanding Angiotensin II Type 1 Receptor Signaling in Vascular Pathophysiology. Hypertension. 2018;71(5):804-810.10.1161/HYPERTENSIONAHA.118.10266589715329581215
]Search in Google Scholar
[
57. Murakami M, Kamimura D, Hirano T. Pleiotropy and Specificity: Insights from the Interleukin 6 Family of Cytokines. Immunity. 2019;50(4):812-831.10.1016/j.immuni.2019.03.027
]Search in Google Scholar
[
58. Wong CK, Lam CW, Wu AK, et al. Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome. Clin Exp Immunol. 2004;136(1):95-10310.1111/j.1365-2249.2004.02415.x
]Search in Google Scholar
[
59. Chen G, Wu D, Guo W, et al. Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest. 2020;130(5):2620-2629.10.1172/JCI137244
]Search in Google Scholar
[
60. Liu J, Li S, Liu J, et al. Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients. EBio- Medicine. 2020;55:102763.
]Search in Google Scholar
[
61. Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020;8(4):420-422.10.1016/S2213-2600(20)30076-X
]Search in Google Scholar
[
62. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med. 2000;342(18):1334-49.10.1056/NEJM200005043421806
]Search in Google Scholar
[
63. Grasselli G, Zangrillo A, Zanella A, et al. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the lombardy Region, Italy. JAMA 2020;323(16):1574.10.1001/jama.2020.5394
]Search in Google Scholar
[
64. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet. 2020;395:1054–62.10.1016/S0140-6736(20)30566-3
]Search in Google Scholar
[
65. McGonagle D, Sharif K, O’Regan A, Bridgewood C. The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease. Autoimmun Rev. 2020;19(6):102537.10.1016/j.autrev.2020.102537719500232251717
]Search in Google Scholar
[
66. Bradford E, Jacobson S, Varasteh J, et al. The value of blood cytokines and chemokines in assessing COPD. Respir Res 2017;18(1).10.1186/s12931-017-0662-2565582029065892
]Search in Google Scholar
[
67. Potere N, Di Nisio M, Cibelli D, et al. Interleukin-6 receptor blockade with subcutaneous tocilizumab in severe COVID-19 pneumonia and hyperinflammation: a case-control study. Ann Rheum Dis. 2021;80(2):1-2.10.1136/annrheumdis-2020-21824332647027
]Search in Google Scholar
[
68. Khoury M, Cuenca J, Cruz FF, et al. Current status of cell-based therapies for respiratory virus infections: applicability to COVID-19. Eur Respir J. 2020;55(6):2000858.10.1183/13993003.00858-2020
]Search in Google Scholar
[
69. Bailey CC, Zhong G, Huang IC, Farzan M. IFITMFamily Proteins: The Cell’s First Line of Antiviral Defense. Annu Rev Virol. 2014;1:261-283.10.1146/annurev-virology-031413-085537
]Search in Google Scholar
[
70. Schoggins JW. Interferon-Stimulated Genes: What Do They All Do? Annu Rev Virol. 2019;6(1):567-584.10.1146/annurev-virology-092818-015756
]Search in Google Scholar
[
71. Kane M, Zang TM, Rihn SJ, et al. Identification of Interferon- Stimulated Genes with Antiretroviral Activity. Cell Host Microbe. 2016;20(3):392-405.10.1016/j.chom.2016.08.005
]Search in Google Scholar
[
72. Sveiven SN, Nordgren TM. Lung-resident mesenchymal stromal cells are tissue-specific regulators of lung homeostasis. Am J Physiol Lung Cell Mol Physiol. 2020;319(2):L197-L210.10.1152/ajplung.00049.2020
]Search in Google Scholar
[
73. Rolandsson Enes S, Åhrman E, Palani A, Hallgren O, Bjermer L, Malmström A, Scheding S, Malmström J, Westergren-Thorsson G. Quantitative proteomic characterization of lung-MSC and bone marrow-MSC using DIA-mass spectrometry. Sci Rep. 2017;7(1):9316.10.1038/s41598-017-09127-y
]Search in Google Scholar
[
74. Sinclair, K., Yerkovich, S. T., & Chambers, D. C.. Mesenchymal stem cells and the lung. Respirology. 2013; 18(3):397–411.10.1111/resp.12050
]Search in Google Scholar
[
75. Foronjy RF, Majka SM. The potential for resident lung mesenchymal stem cells to promote functional tissue regeneration: understanding microenvironmental cues. Cells. 2012;1(4):874.10.3390/cells1040874
]Search in Google Scholar
[
76. Luo XY, Meng XJ, Cao DC, et al. Transplantation of bone marrow mesenchymal stromal cells attenuates liver fibrosis in mice by regulating macrophage subtypes. Stem Cell Res Ther. 2019;10(1):16.10.1186/s13287-018-1122-8
]Search in Google Scholar
[
77. Wang J, Wang BJ, Yang JC, et al. [Research advances in the mechanism of pulmonary fibrosis induced by coronavirus disease 2019 and the corresponding therapeutic measures]. Zhonghua Shao Shang Za Zhi. 2020;36(8):691-697.
]Search in Google Scholar
[
78. Walter J, Ware LB, Matthay MA. Mesenchymal stem cells: mechanisms of potential therapeutic benefit in ARDS and sepsis. Lancet Respir Med. 2014;2(12):1016-26.10.1016/S2213-2600(14)70217-6
]Search in Google Scholar
[
79. Atluri S, Manchikanti L, Hirsch JA. Expanded Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) as a Therapeutic Strategy in Managing Critically Ill COVID-19 Patients: The Case for Compassionate Use. Pain Physician. 2020;23(2):E71-E83.10.36076/ppj.2020/23/E71
]Search in Google Scholar
[
80. Leng Z, Zhu R, Hou W, et al. Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia. Aging Dis. 2020;11(2):216-228.10.14336/AD.2020.0228
]Search in Google Scholar
[
81. McIntyre LA, Moher D, Fergusson DA, et al. Efficacy of Mesenchymal Stromal Cell Therapy for Acute Lung Injury in Preclinical Animal Models: A Systematic Review. PLoS One. 2016;11(1):e0147170.10.1371/journal.pone.0147170
]Search in Google Scholar
[
82. Behnke J, Kremer S, Shahzad T, et al. MSC Based Therapies-New Perspectives for the Injured Lung. J Clin Med. 2020;9(3):682.10.3390/jcm9030682
]Search in Google Scholar
[
83. Majolo F, da Silva GL, Vieira L, Timmers LFSM, Laufer S, Goettert MI. Review of Trials Currently Testing Stem Cells for Treatment of Respiratory Diseases: Facts Known to Date and Possible Applications to COVID-19. Stem Cell Rev Rep. 2021;17(1):44-55.10.1007/s12015-020-10033-6
]Search in Google Scholar
[
84. Wilson JG, Liu KD, Zhuo H, et al. Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial. Lancet Respir Med. 2015;3(1):24-32.10.1016/S2213-2600(14)70291-7
]Search in Google Scholar
[
85. Matthay MA, Calfee CS, Zhuo H, et al. Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial. Lancet Respir Med. 2019;7(2):154-162.10.1016/S2213-2600(18)30418-1
]Search in Google Scholar
[
86. Harrell CR, Sadikot R, Pascual J, et al. Mesenchymal Stem Cell-Based Therapy of Inflammatory Lung Diseases: Current Understanding and Future Perspectives. Stem Cells Int. 2019;2019:4236973.10.1155/2019/4236973652579431191672
]Search in Google Scholar
[
87. Liu S, Peng D, Qiu H, Yang K, Fu Z, Zou L. Mesenchymal stem cells as a potential therapy for COVID-19. Stem Cell Res Ther. 2020;11(1):169.10.1186/s13287-020-01678-8719703132366290
]Search in Google Scholar
[
88. Rajarshi K, Chatterjee A, Ray S. Combating COVID-19 with mesenchymal stem cell therapy. Biotechnol Rep (Amst). 2020;26:e00467.10.1016/j.btre.2020.e00467722467132420049
]Search in Google Scholar
[
89. Zhang Y, Ding J, Ren S, et al. Intravenous infusion of human umbilical cord Wharton’s jelly-derived mesenchymal stem cells as a potential treatment for patients with COVID-19 pneumonia. Stem Cell Res Ther. 2020;11(1):207.10.1186/s13287-020-01725-4725155832460839
]Search in Google Scholar
[
90. Golchin A, Seyedjafari E, Ardeshirylajimi A. Mesenchymal Stem Cell Therapy for COVID-19: Present or Future. Stem Cell Rev Rep. 2020;16(3):427-433.10.1007/s12015-020-09973-w715251332281052
]Search in Google Scholar
[
91. Sengupta V, Sengupta S, Lazo A, Woods P, Nolan A, Bremer N. Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19. Stem Cells Dev. 2020;29(12):747-754.10.1089/scd.2020.0080731020632380908
]Search in Google Scholar
[
92. Hashemian SR, Aliannejad R, Zarrabi M, et al. Mesenchymal stem cells derived from perinatal tissues for treatment of critically ill COVID-19-induced ARDS patients: a case series. Stem Cell Res Ther. 2021;12(1):9110.1186/s13287-021-02165-4784480433514427
]Search in Google Scholar
[
93. Gorman E, Shankar-Hari M, Hopkins P, et al. Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration in COVID-19 (REALIST-COVID-19): A structured summary of a study protocol for a randomised, controlled trial. Trials. 2020;21(1):46210.1186/s13063-020-04416-w726775632493473
]Search in Google Scholar
[
94. Xu X, Jiang W, Chen L, et al. Evaluation of the safety and efficacy of using human menstrual blood-derived mesenchymal stromal cells in treating severe and critically ill COVID-19 patients: An exploratory clinical trial. Clin Transl Med. 2021;11(2):e297.10.1002/ctm2.297783995933634996
]Search in Google Scholar
[
95. Liang B, Chen J, Li T, et al. Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells: A case report. Medicine (Baltimore). 2020;99(31):e21429.10.1097/MD.0000000000021429740280032756149
]Search in Google Scholar
[
96. Leng Z, Zhu R, Hou W, et al. Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia. Aging Dis. 2020;11(2):216-228.10.14336/AD.2020.0228706946532257537
]Search in Google Scholar
[
97. Chen Y, Zhang Q, Peng W, et al. Efficacy and safety of mesenchymal stem cells for the treatment of patients infected with COVID-19: a systematic review and metaanalysis protocol. BMJ Open. 2020;10(12):e042085.10.1136/bmjopen-2020-042085775087133371042
]Search in Google Scholar
[
98. Sánchez-Guijo F, García-Arranz M, López-Parra M, et al. Adipose-derived mesenchymal stromal cells for the treatment of patients with severe SARS-CoV-2 pneumonia requiring mechanical ventilation. A proof of concept study. EClinicalMedicine. 2020;25:100454.10.1016/j.eclinm.2020.100454734861032838232
]Search in Google Scholar
[
99. Lanzoni G, Linetsky E, Correa D, et al. Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trial. Stem Cells Transl Med. 2021.10.1002/sctm.20-0472804604033400390
]Search in Google Scholar
[
100. Qu W, Wang Z, Hare JM, et al. Cell-based therapy to reduce mortality from COVID-19: Systematic review and meta-analysis of human studies on acute respiratory distress syndrome. Stem Cells Transl Med. 2020;9(9):1007-1022.10.1002/sctm.20-0146730074332472653
]Search in Google Scholar
[
101. Golchin A, Seyedjafari E, Ardeshirylajimi A. Mesenchymal Stem Cell Therapy for COVID-19: Present or Future. Stem Cell Rev Rep. 2020;16(3):427-433.10.1007/s12015-020-09973-w715251332281052
]Search in Google Scholar
[
102. Khoury M, Cuenca J, Cruz FF, Figueroa FE, Rocco PRM, Weiss DJ. Current status of cell-based therapies for respiratory virus infections: applicability to COVID-19. Eur Respir J. 2020;55(6):2000858.10.1183/13993003.00858-2020714427332265310
]Search in Google Scholar
[
103. Yu F, Jia R, Tang Y, Liu J, Wei B. SARS-CoV-2 infection and stem cells: Interaction and intervention. Stem Cell Res. 2020;46:101859.10.1016/j.scr.2020.101859726322132570174
]Search in Google Scholar
[
104. Zumla A, Wang FS, Ippolito G, et al. Reducing mortality and morbidity in patients with severe COVID-19 disease by advancing ongoing trials of Mesenchymal Stromal (stem) Cell (MSC) therapy - Achieving global consensus and visibility for cellular host-directed therapies. Int J Infect Dis. 2020;96:431-439.10.1016/j.ijid.2020.05.040723149732425638
]Search in Google Scholar
[
105. Lukomska B, Stanaszek L, Zuba-Surma E, Legosz P, Sarzynska S, Drela K. Challenges and Controversies in Human Mesenchymal Stem Cell Therapy. Stem Cells Int. 2019; 2019:9628536.10.1155/2019/9628536648104031093291
]Search in Google Scholar
[
106. von Bahr L, Sundberg B, Lönnies L, et al. Long-term complications, immunologic effects, and role of passage for outcome in mesenchymal stromal cell therapy. Biol Blood Marrow Transplant. 2012;18(4):557-64.10.1016/j.bbmt.2011.07.02321820393
]Search in Google Scholar
[
107. Price MJ, Chou CC, Frantzen M, et al. Intravenous mesenchymal stem cell therapy early after reperfused acute myocardial infarction improves left ventricular function and alters electrophysiologic properties. Int J Cardiol. 2006;111(2):231-9.10.1016/j.ijcard.2005.07.03616246440
]Search in Google Scholar
[
108. Jeong JO, Han JW, Kim JM, et al. Malignant tumor formation after transplantation of short-term cultured bone marrow mesenchymal stem cells in experimental myocardial infarction and diabetic neuropathy. Circ Res. 2011;108(11):1340-7.10.1161/CIRCRESAHA.110.239848310974121493893
]Search in Google Scholar
[
109. Breitbach M, Bostani T, Roell W, et al. Potential risks of bone marrow cell transplantation into infarcted hearts. Blood. 2007;110(4):1362-9.10.1182/blood-2006-12-06341217483296
]Search in Google Scholar
[
110. Kan C, Chen L, Hu Y, et al. Microenvironmental factors that regulate mesenchymal stem cells: lessons learned from the study of heterotopic ossification. Histol Histopathol. 2017;32(10):977-985.
]Search in Google Scholar
[
111. Ljujic B, Milovanovic M, Volarevic V, et al. Human mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in mice. Sci Rep. 2013;3:2298.10.1038/srep02298372551223892388
]Search in Google Scholar
[
112. Miloradovic D, Miloradovic D, Markovic BS, et al. The Effects of Mesenchymal Stem Cells on Antimelanoma Immunity Depend on the Timing of Their Administration. Stem Cells Int. 2020;2020:8842659.10.1155/2020/8842659736893632695181
]Search in Google Scholar