<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Chorioamnionitis is one of the most common causes of preterm premature rupture of fetal membranes and consequent preterm birth. The variety of mechanisms underlie pathophysiology of chorioamnionitis represents its greatest enigma. The unspecific clinical manifestations of chorioamnionitis considered an aggravating issue for perinatologist to diagnose it timely. There are no absolutely sensitive, non-invasive diagnostic procedures for certain establishment of chorioamnionitis diagnosis. The more sensitive diagnostic procedures are also invasive, so the question of their application in routine practice arises. Certainly, the perinatologist is always in a dilemma when there is a suspicion of chorioamnionitis, whether and how it should be treated, having in mind the facts about possible side effects on the fetus, but also on the mother. This paper presents a summary of all known facts about the etiopathogenesis, classification and clinical manifestations of chorioamnionitis, providing a basis for further research regarding the identification of more sensitive diagnostic markers, as well as the treatment of this condition.</p>
</abstract>

Chorioamnionitis is one of the most common causes of preterm premature rupture of fetal membranes and consequent preterm birth. The variety of mechanisms underlie pathophysiology of chorioamnionitis represents its greatest enigma. The unspecific clinical manifestations of chorioamnionitis considered an aggravating issue for perinatologist to diagnose it timely. There are no absolutely sensitive, non-invasive diagnostic procedures for certain establishment of chorioamnionitis diagnosis. The more sensitive diagnostic procedures are also invasive, so the question of their application in routine practice arises. Certainly, the perinatologist is always in a dilemma when there is a suspicion of chorioamnionitis, whether and how it should be treated, having in mind the facts about possible side effects on the fetus, but also on the mother. This paper presents a summary of all known facts about the etiopathogenesis, classification and clinical manifestations of chorioamnionitis, providing a basis for further research regarding the identification of more sensitive diagnostic markers, as well as the treatment of this condition.

The Chorioamnionitis - Still an Enigma in Perinatology

Faculty of Medical Sciences, Department of Gynecology and obstetrics

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"The Chorioamnionitis - Still an Enigma in Perinatology"}

Chorioamnionitis is one of the most common causes of preterm premature rupture of fetal membranes and consequent preterm birth. The variety of mechanisms...

The Chorioamnionitis - Still an Enigma in Perinatology

Published Online: Jun 24, 2024

Page range: -

Received: Feb 08, 2021

Accepted: Feb 18, 2021

DOI: https://doi.org/10.2478/sjecr-2021-0007

Keywords
Chorioamnionitis, preterm birth, inflammation, infection

© 2024 Mirjana Varjacic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The Chorioamnionitis - Still an Enigma in Perinatology

Published Online: Jun 24, 2024

Page range: -

Received: Feb 08, 2021

Accepted: Feb 18, 2021

DOI: https://doi.org/10.2478/sjecr-2021-0007

KeywordsChorioamnionitis, preterm birth, inflammation, infection

© 2024 Mirjana Varjacic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
Chorioamnionitis, preterm birth, inflammation, infection