<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Osteoarthritis is a degenerative, painful and irreversible disease that affects millions of people worldwide. The causes and mechanisms of osteoarthritis have not been fully understood. Vitamin D is an essential factor in bone metabolism. Its actions are mediated by the vitamin D receptor, a transcription factor that controls gene expression, thus maintaining calcium and phosphate homeostasis. Vitamin D has been hypothesized to play essential role in a number of musculoskeletal diseases including osteoarthritis, and its deficiency is prevalent among osteoarthritis patients. A large number of studies have been done regarding the effects of vitamin D in pathogenesis and progression of osteoarthritis, as well as its use a therapeutic agent. Up to date, studies have provided controversial results, and no consensus concerning this matter was achieved. With this review, we aim to explore current data on the possible role of vitamin D and its receptor in pathogenesis of osteoarthritis and assess the efficiency of vitamin D supplementation as a therapeutic strategy.</p>
</abstract>

Osteoarthritis is a degenerative, painful and irreversible disease that affects millions of people worldwide. The causes and mechanisms of osteoarthritis have not been fully understood. Vitamin D is an essential factor in bone metabolism. Its actions are mediated by the vitamin D receptor, a transcription factor that controls gene expression, thus maintaining calcium and phosphate homeostasis. Vitamin D has been hypothesized to play essential role in a number of musculoskeletal diseases including osteoarthritis, and its deficiency is prevalent among osteoarthritis patients. A large number of studies have been done regarding the effects of vitamin D in pathogenesis and progression of osteoarthritis, as well as its use a therapeutic agent. Up to date, studies have provided controversial results, and no consensus concerning this matter was achieved. With this review, we aim to explore current data on the possible role of vitamin D and its receptor in pathogenesis of osteoarthritis and assess the efficiency of vitamin D supplementation as a therapeutic strategy.

Vitamin D and Vitamin D Receptor Gene in Osteoarthritis

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Vitamin D and Vitamin D Receptor Gene in Osteoarthritis"}

Osteoarthritis is a degenerative, painful and irreversible disease that affects millions of people worldwide. The causes and mechanisms of osteoarthritis have...

Vitamin D and Vitamin D Receptor Gene in Osteoarthritis

Published Online: Dec 24, 2022

Page range: 285 - 290

Received: Nov 09, 2018

Accepted: Jan 09, 2019

DOI: https://doi.org/10.2478/sjecr-2018-0075

Keywords
Osteoarthritis, vitamin D, vitamin D receptor, inflammation

© 2018 Vladimir Vranic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Vitamin D and Vitamin D Receptor Gene in Osteoarthritis

Published Online: Dec 24, 2022

Page range: 285 - 290

Received: Nov 09, 2018

Accepted: Jan 09, 2019

DOI: https://doi.org/10.2478/sjecr-2018-0075

KeywordsOsteoarthritis, vitamin D, vitamin D receptor, inflammation

© 2018 Vladimir Vranic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
Osteoarthritis, vitamin D, vitamin D receptor, inflammation