<abstract xmlns="http://www.w3.org/1999/xhtml"><p>In absence of clear clinical signs and clear definition, neonatal sepsis is still one of the major cause of morbidity and mortality. Most researchs in past time was directional on finding new biomarkers with greater sensitivity and specificity in detection of neonatal sepsis. The aim of our study was to investigate if presepsin obtained from tracheal asprate in intubated newborns, can be a novel biomarker of systemic bacterial infection. Our ‘’case control’’ study included 60 newborns, 11 with suspected neonatal sepsis. Tracheal aspirate for examination was taken in the usual toilets, in aseptic conditions, by lavage with 2 ml of 0.9% NaCl in Mucus suction set. In the same day were mesured presepsin (blood), CRP, PCT, leukocytes and neutrophyls, as well as blood culture. Our research showed higher levels for PCT and presepsin (blood) in septic newborns, as well as in newborns with clinical signs of SIRS. Presepsin obtained from a tracheal aspirate had high score for septic newborns. As the coefficients of simple linear correlation showed, there was quantitative agreement between presepsin (blood) with presepsin (tracheal aspirate)- increase in the value of one leads to an increase in other. In conjunction with an already validated markers of infection, presepsin obtained from tracheal aspirate cam be turned on in diagnostic procedures.</p></abstract>

In absence of clear clinical signs and clear definition, neonatal sepsis is still one of the major cause of morbidity and mortality. Most researchs in past time was directional on finding new biomarkers with greater sensitivity and specificity in detection of neonatal sepsis. The aim of our study was to investigate if presepsin obtained from tracheal asprate in intubated newborns, can be a novel biomarker of systemic bacterial infection. Our ‘’case control’’ study included 60 newborns, 11 with suspected neonatal sepsis. Tracheal aspirate for examination was taken in the usual toilets, in aseptic conditions, by lavage with 2 ml of 0.9% NaCl in Mucus suction set. In the same day were mesured presepsin (blood), CRP, PCT, leukocytes and neutrophyls, as well as blood culture. Our research showed higher levels for PCT and presepsin (blood) in septic newborns, as well as in newborns with clinical signs of SIRS. Presepsin obtained from a tracheal aspirate had high score for septic newborns. As the coefficients of simple linear correlation showed, there was quantitative agreement between presepsin (blood) with presepsin (tracheal aspirate)- increase in the value of one leads to an increase in other. In conjunction with an already validated markers of infection, presepsin obtained from tracheal aspirate cam be turned on in diagnostic procedures.

Can a Presepsin (Scd14-St) Obtained from Tracheal Aspirate Be a Biomarker for Early- Onset Neonatal Sepsis

Faculty of Medical Sciences, Department of Pediatrics

Faculty of Medical Sciences, Department of Clinical Pharmacy

Department for the control and prevention of hospital infections

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

In absence of clear clinical signs and clear definition, neonatal sepsis is still one of the major cause of morbidity and mortality. Most researchs in past...

Can a Presepsin (Scd14-St) Obtained from Tracheal Aspirate Be a Biomarker for Early- Onset Neonatal Sepsis

Published Online: Dec 21, 2020

Page range: 225 - 230

Received: May 16, 2018

Accepted: Jul 11, 2018

DOI: https://doi.org/10.2478/sjecr-2018-0021

Keywords
newborn, presepsin, tracheal aspirate, sepsis

© 2020 Dragana Savic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Can a Presepsin (Scd14-St) Obtained from Tracheal Aspirate Be a Biomarker for Early- Onset Neonatal Sepsis

Published Online: Dec 21, 2020

Page range: 225 - 230

Received: May 16, 2018

Accepted: Jul 11, 2018

DOI: https://doi.org/10.2478/sjecr-2018-0021

Keywordsnewborn, presepsin, tracheal aspirate, sepsis

© 2020 Dragana Savic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
newborn, presepsin, tracheal aspirate, sepsis