<abstract xmlns="http://www.w3.org/1999/xhtml"> Epilepsy is a chronic neurological disorder characterised by recurrent epileptic seizures. Understanding the mechanisms by which it initiates and develops, as well as its modulating factors, are of great scientific interest. Experimental models of epilepsy are useful for understanding these mechanisms. Homocysteine, an amino acid endogenously generated in the body, together with its reactive metabolite, homocysteine thiolactone (HCT), is recognised as a risk factor for a variety of diseases. HCT-induced seizures are a model of generalised epilepsy in which the coexistence of two types of epileptic activity has been documented. Th e complex interplay between sleep and epilepsy is still only poorly understood. Additionally, the relationship between physical exercise and epilepsy is quite intriguing, especially the mechanism underlying this relationship. Th e role of nitric oxide (NO)-mediated neurotransmission in the development of epileptic activity is highly debated in the existing scientific literature . In this review article, we described the modulation of epileptic activity in rats and focused on sleep, physical activity and NO-mediated signalling. First, we explain the characteristics of the experimental models of epileptic activity and the unique features of HCT-induced seizures. Second, the modulating eff ects of sleep and regular physical exercise training on epileptic activity, along with works from the authors, are discussed. Finally, the anticonvulsive eff ects of NO that is produced via nNOS and iNOS in HCT-induced seizures are reviewed.</abstract>

Epilepsy is a chronic neurological disorder characterised by recurrent epileptic seizures. Understanding the mechanisms by which it initiates and develops, as well as its modulating factors, are of great scientific interest. Experimental models of epilepsy are useful for understanding these mechanisms. Homocysteine, an amino acid endogenously generated in the body, together with its reactive metabolite, homocysteine thiolactone (HCT), is recognised as a risk factor for a variety of diseases. HCT-induced seizures are a model of generalised epilepsy in which the coexistence of two types of epileptic activity has been documented. Th e complex interplay between sleep and epilepsy is still only poorly understood. Additionally, the relationship between physical exercise and epilepsy is quite intriguing, especially the mechanism underlying this relationship. Th e role of nitric oxide (NO)-mediated neurotransmission in the development of epileptic activity is highly debated in the existing scientific literature . In this review article, we described the modulation of epileptic activity in rats and focused on sleep, physical activity and NO-mediated signalling. First, we explain the characteristics of the experimental models of epileptic activity and the unique features of HCT-induced seizures. Second, the modulating eff ects of sleep and regular physical exercise training on epileptic activity, along with works from the authors, are discussed. Finally, the anticonvulsive eff ects of NO that is produced via nNOS and iNOS in HCT-induced seizures are reviewed.

Modulation of Epileptic Activity in Rats: Focus on Sleep, Physical Exercise and Nitric Oxide–mediated Neurotransmission in a Model of Homocysteine Thiolactone–induced Seizures

Laboratory of Neurophysiology, Institute of Medical Physiology “Richard Burian”, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia

Serbian Academy of Sciences and Arts, 11000 Belgrade, Serbia

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Epilepsy is a chronic neurological disorder characterised by recurrent epileptic seizures. Understanding the mechanisms by which it initiates and develops, as...

Modulation of Epileptic Activity in Rats: Focus on Sleep, Physical Exercise and Nitric Oxide–mediated Neurotransmission in a Model of Homocysteine Thiolactone–induced Seizures

Published Online: Apr 23, 2014

Page range: 3 - 10

DOI: https://doi.org/10.2478/sjecr-2014-0001

Keywords
homocysteine, seizures, sleep, physical activity, nitric oxide

© 2014

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Modulation of Epileptic Activity in Rats: Focus on Sleep, Physical Exercise and Nitric Oxide–mediated Neurotransmission in a Model of Homocysteine Thiolactone–induced Seizures

Published Online: Apr 23, 2014

Page range: 3 - 10

DOI: https://doi.org/10.2478/sjecr-2014-0001

Keywordshomocysteine, seizures, sleep, physical activity, nitric oxide

© 2014

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
homocysteine, seizures, sleep, physical activity, nitric oxide