<abstract xmlns="http://www.w3.org/1999/xhtml"><p><bold>Introduction</bold>. Multiple eruptive dermatofibromas are described in association with different immune-mediated conditions like SLE, pemphigus, myasthenia gravis, HIV infection, organ transplantation, acute myeloid leukemia, ulcerative colitis, atopic dermatitis and immunosuppressive therapy. <bold>Case Report.</bold> A forty-five year-old woman presented at our Department with over 20 dermatofibromas on her trunk and extremities developed spontaneously over the last 3 years, out of which more than 10 lesions developed over the previous year. The patient was diagnosed with systemic lupus erythematosus before the onset of lesions and was treated with different immunomodulatory agents (corticosteroids, methotrexate, antimalarials, azathioprine, belimumab, anti IL-6 antibody). Dermoscopy of different lesions revealed different dermatoscopic patterns without pattern predominance. A biopsy specimen of one lesion confirmed the diagnosis. <bold>Conclusion</bold>. There are few cases reports describing a possible link between systemic lupus erythematosus and multiple dermatofibromas. The mechanism is still unknown but is believed to be due to the altered immunity in immune-mediated diseases.</p></abstract>

Introduction. Multiple eruptive dermatofibromas are described in association with different immune-mediated conditions like SLE, pemphigus, myasthenia gravis, HIV infection, organ transplantation, acute myeloid leukemia, ulcerative colitis, atopic dermatitis and immunosuppressive therapy. Case Report. A forty-five year-old woman presented at our Department with over 20 dermatofibromas on her trunk and extremities developed spontaneously over the last 3 years, out of which more than 10 lesions developed over the previous year. The patient was diagnosed with systemic lupus erythematosus before the onset of lesions and was treated with different immunomodulatory agents (corticosteroids, methotrexate, antimalarials, azathioprine, belimumab, anti IL-6 antibody). Dermoscopy of different lesions revealed different dermatoscopic patterns without pattern predominance. A biopsy specimen of one lesion confirmed the diagnosis. Conclusion. There are few cases reports describing a possible link between systemic lupus erythematosus and multiple dermatofibromas. The mechanism is still unknown but is believed to be due to the altered immunity in immune-mediated diseases.

Multiple Eruptive Dermatofibromas in Patient with Systemic Lupus Erythematosus

Department of Dermatology, Faculty of Medicine

Department of Rheumatology, Faculty of Medicine

Institute of Pathology and Forensic Medicine, Faculty of Medicine

Serbian Journal of Dermatology and Venereology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Multiple Eruptive Dermatofibromas in Patient with Systemic Lupus Erythematosus"}

Introduction. Multiple eruptive dermatofibromas are described in association with different immune-mediated conditions like SLE, pemphigus, myasthenia gravis,...

Multiple Eruptive Dermatofibromas in Patient with Systemic Lupus Erythematosus

Published Online: Apr 24, 2020

Page range: 137 - 140

Received: Dec 23, 2019

Accepted: Dec 29, 2019

DOI: https://doi.org/10.2478/sjdv-2019-0020

Keywords
Lupus Erythematosus, Systemic, Histiocytoma, Benign Fibrous, Immunosuppressive Agents, Autoimmune Diseases, Immunomodulation, Dermoscopy

© 2019 Monika Janc et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Multiple Eruptive Dermatofibromas in Patient with Systemic Lupus Erythematosus

Published Online: Apr 24, 2020

Page range: 137 - 140

Received: Dec 23, 2019

Accepted: Dec 29, 2019

DOI: https://doi.org/10.2478/sjdv-2019-0020

KeywordsLupus Erythematosus, Systemic, Histiocytoma, Benign Fibrous, Immunosuppressive Agents, Autoimmune Diseases, Immunomodulation, Dermoscopy

© 2019 Monika Janc et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Lupus Erythematosus, Systemic, Histiocytoma, Benign Fibrous, Immunosuppressive Agents, Autoimmune Diseases, Immunomodulation, Dermoscopy