<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Ivermectin 2 mg/kg single dose reduced worm load by 83.3 % (75.0 – 91.7 %) for rats experimentally infected with 20 Gnathostoma spinigerum advanced third-stage larvae administered at week 1, with sacrifice at week 15 post-infection. Some larvae recovered from the muscles of treated rats were found to be grossly deformed in appearance. Morphological changes in the Gnathostoma larvae were clearly observed. The internal structures of the deformed larvae showed significant degeneration in the esophageal glandular tissues. The esophageal lumen branched irregularly and occupied a wider area in the center of the esophagus. The epithelial cells thickened along these branches. The esophageal gland ducts were completely destroyed. The excretory ability of the esophageal cell glands may be depressed, causing loss of function. It is suggested that ivermectin is effective against Gnathostoma larvae due to worm recovery reductions. The drug efficacy appears to generate by esophageal destruction of the worms.</p></abstract>

Ivermectin 2 mg/kg single dose reduced worm load by 83.3 % (75.0 – 91.7 %) for rats experimentally infected with 20 Gnathostoma spinigerum advanced third-stage larvae administered at week 1, with sacrifice at week 15 post-infection. Some larvae recovered from the muscles of treated rats were found to be grossly deformed in appearance. Morphological changes in the Gnathostoma larvae were clearly observed. The internal structures of the deformed larvae showed significant degeneration in the esophageal glandular tissues. The esophageal lumen branched irregularly and occupied a wider area in the center of the esophagus. The epithelial cells thickened along these branches. The esophageal gland ducts were completely destroyed. The excretory ability of the esophageal cell glands may be depressed, causing loss of function. It is suggested that ivermectin is effective against Gnathostoma larvae due to worm recovery reductions. The drug efficacy appears to generate by esophageal destruction of the worms.

Esophageal deformation of Gnathostoma spinigerum in ivermectin-treated rats, and anthelminthic efficacy

Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, 420/6 Ratchawithi Road, Bangkok, 10400, Thailand

Department of Parasitology, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University, Mahidol, Thailand

Helminthologia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Ivermectin 2 mg/kg single dose reduced worm load by 83.3 % (75.0 – 91.7 %) for rats experimentally infected with 20 Gnathostoma spinigerum advanced third-stage...

Esophageal deformation of Gnathostoma spinigerum in ivermectin-treated rats, and anthelminthic efficacy

Published Online: May 26, 2010

Page range: 88 - 93

DOI: https://doi.org/10.2478/s11687-010-0014-y

Keywords
Esophagus tissues, Gnathostoma spinigerum, ivermectin, rats, treatment efficacy

© 2010 Institute of Parasitology, SAS, Košice, Slovakia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Esophageal deformation of Gnathostoma spinigerum in ivermectin-treated rats, and anthelminthic efficacy

Published Online: May 26, 2010

Page range: 88 - 93

DOI: https://doi.org/10.2478/s11687-010-0014-y

KeywordsEsophagus tissues, Gnathostoma spinigerum, ivermectin, rats, treatment efficacy

© 2010 Institute of Parasitology, SAS, Košice, Slovakia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Esophagus tissues, Gnathostoma spinigerum, ivermectin, rats, treatment efficacy