<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>To enhance the effect of treatment method of Trichinellosis with mebendazole, lipid peroxidation processes (LPP) in blood of Wistar rats experimentally infected with Trichinella spiralis were investigated. In accordance with health condition of infected rats treated with mebendazole and combination of mebendazole and AKβ vitamin complex, dynamics of the main values of the LPP (such as: activity of superoxide dismutase (SOD) and catalase (CAT) in erythrocytes and malonic dialdehyde (MDA) concentration in blood serum) were analyzed. It was concluded that mebendazole amplifies the LPP in rat’s blood. Additional administrations of the AKβ vitamin complex allow improvement of LPP parameters, raising compensatory-adaptive reactions of the host organism and reducing the rate of the experimental animal’s mortality.</p></abstract>

To enhance the effect of treatment method of Trichinellosis with mebendazole, lipid peroxidation processes (LPP) in blood of Wistar rats experimentally infected with Trichinella spiralis were investigated. In accordance with health condition of infected rats treated with mebendazole and combination of mebendazole and AKβ vitamin complex, dynamics of the main values of the LPP (such as: activity of superoxide dismutase (SOD) and catalase (CAT) in erythrocytes and malonic dialdehyde (MDA) concentration in blood serum) were analyzed. It was concluded that mebendazole amplifies the LPP in rat’s blood. Additional administrations of the AKβ vitamin complex allow improvement of LPP parameters, raising compensatory-adaptive reactions of the host organism and reducing the rate of the experimental animal’s mortality.

Increasing antioxidant protection during mebendazole and AKβ vitamin complex treatment of experimental trichinellosis in rats

Department of Biology, Belarus State Medical University, Dzerzhinskogo Street 83, 220116, Minsk, Belorussia

Department of Laboratory Animal Breeding and Hygiene, Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20, Prague 4-Krc, Czech Republic

Department of Zoology and Fisheries, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences in Prague, Kamycka 129, 165 21, Prague 6-Suchdol, Czech Republic

Helminthologia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

To enhance the effect of treatment method of Trichinellosis with mebendazole, lipid peroxidation processes (LPP) in blood of Wistar rats experimentally...

Increasing antioxidant protection during mebendazole and AKβ vitamin complex treatment of experimental trichinellosis in rats

Published Online: Sep 08, 2009

Page range: 145 - 150

DOI: https://doi.org/10.2478/s11687-009-0028-5

Keywords
AKβ vitamin complex, catalase, lipid peroxidation process, malonic dialdehyde, mebendazole, superoxide dismutase, Trichinella spiralis

© 2009 Institute of Parasitology, SAS, Košice, Slovakia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Increasing antioxidant protection during mebendazole and AKβ vitamin complex treatment of experimental trichinellosis in rats

Published Online: Sep 08, 2009

Page range: 145 - 150

DOI: https://doi.org/10.2478/s11687-009-0028-5

KeywordsAKβ vitamin complex, catalase, lipid peroxidation process, malonic dialdehyde, mebendazole, superoxide dismutase, Trichinella spiralis

© 2009 Institute of Parasitology, SAS, Košice, Slovakia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
AKβ vitamin complex, catalase, lipid peroxidation process, malonic dialdehyde, mebendazole, superoxide dismutase, Trichinella spiralis