<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Background</h3>
<p>In this study, we aimed to analyze the correlations of high expressions of micro ribonucleic acids (miRNAs) with traditional proteins and prognosis of breast cancer.</p>
</sec>
<sec><h3>Methods</h3>
<p>The clinical data of 60 breast cancer patients treated from August 2018 to July 2019 were retrospectively analyzed. All the patients received radical mastectomy combined with postoperative adjuvant chemoradiotherapy and were followed up for 3 years after treatment. The 3-year survival was recorded. The surviving patients were included in a good prognosis group, and the deceased ones were assigned to a poor prognosis group. The levels of miRNAs (miR-182, miR-155, and miR-217) and traditional breast cancer proteins [estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (CerbB-2/HER-2), and cell proliferation factor-67 (Ki-67)] were measured. Receiver operating characteristic (ROC) curve was plotted to investigate the predictive value of miRNA levels for poor prognosis.</p>
</sec>
<sec><h3>Results</h3>
<p>The relative expressions of miR-182, miR-155 and miR-217 were negatively correlated with ER and PR (r&lt;0, P&lt;0.05), but positively correlated with positive Ki-67 expression (r>0, P&lt;0.05). High relative expressions of miR-182, miR-155 and miR-217 and positive Ki-67 expression were risk factors for poor prognosis, and the positive expressions of ER and PR were protective factors (OR&lt;1, P&lt;0.05). The areas under the curves of the relative expressions of miR-182, miR-155 and miR-217 and combined detection for predicting poor prognosis all exceeded 0.70. The combined detection had the highest predictive value.</p>
</sec>
<sec><h3>Conclusions</h3>
<p>The high expressions of miR-182, miR-155 and miR-217 are correlated with the expressions of traditional breast cancer proteins ER, PR, and Ki-67, and may predict the prognosis of breast cancer patients.</p>
</sec>
</abstract>

Background
In this study, we aimed to analyze the correlations of high expressions of micro ribonucleic acids (miRNAs) with traditional proteins and prognosis of breast cancer.

Methods
The clinical data of 60 breast cancer patients treated from August 2018 to July 2019 were retrospectively analyzed. All the patients received radical mastectomy combined with postoperative adjuvant chemoradiotherapy and were followed up for 3 years after treatment. The 3-year survival was recorded. The surviving patients were included in a good prognosis group, and the deceased ones were assigned to a poor prognosis group. The levels of miRNAs (miR-182, miR-155, and miR-217) and traditional breast cancer proteins [estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (CerbB-2/HER-2), and cell proliferation factor-67 (Ki-67)] were measured. Receiver operating characteristic (ROC) curve was plotted to investigate the predictive value of miRNA levels for poor prognosis.

Results
The relative expressions of miR-182, miR-155 and miR-217 were negatively correlated with ER and PR (r<0, P<0.05), but positively correlated with positive Ki-67 expression (r>0, P<0.05). High relative expressions of miR-182, miR-155 and miR-217 and positive Ki-67 expression were risk factors for poor prognosis, and the positive expressions of ER and PR were protective factors (OR<1, P<0.05). The areas under the curves of the relative expressions of miR-182, miR-155 and miR-217 and combined detection for predicting poor prognosis all exceeded 0.70. The combined detection had the highest predictive value.

Conclusions
The high expressions of miR-182, miR-155 and miR-217 are correlated with the expressions of traditional breast cancer proteins ER, PR, and Ki-67, and may predict the prognosis of breast cancer patients.

Correlations of high miRNA expressions with traditional proteins and prognosis of breast cancer

Revista Romana de Medicina de Laborator

This work is licensed under the Creative Commons Attribution 4.0 International License.

Background
In this study, we aimed to analyze the correlations of high expressions of micro ribonucleic acids (miRNAs) with traditional proteins and prognosis of breast cancer.

Methods
The clinical data of 60 breast cancer patients treated from August 2018 to July 2019 were retrospectively analyzed. All the patients received radical mastectomy combined with postoperative adjuvant chemoradiotherapy and were followed up for 3 years after treatment. The 3-year survival was recorded. The surviving patients were included in a good prognosis group, and the deceased ones were assigned to a poor prognosis group. The levels of miRNAs (miR-182, miR-155, and miR-217) and traditional breast cancer proteins [estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (CerbB-2/HER-2), and cell proliferation factor-67 (Ki-67)] were measured. Receiver operating characteristic (ROC) curve was plotted to investigate the predictive value of miRNA levels for poor prognosis.

Results
The relative expressions of miR-182, miR-155 and miR-217 were negatively correlated with ER and PR (r0, P<0.05). High relative expressions of miR-182, miR-155 and miR-217 and positive Ki-67 expression were risk factors for poor prognosis, and the positive expressions of ER and PR were protective factors (OR<1, P<0.05). The areas under the curves of the relative expressions of miR-182, miR-155 and miR-217 and combined detection for predicting poor prognosis all exceeded 0.70. The combined detection had the highest predictive value.

Conclusions
The high expressions of miR-182, miR-155 and miR-217 are correlated with the expressions of traditional breast cancer proteins ER, PR, and Ki-67, and may predict the prognosis of breast cancer patients.

Background
In this study, we aimed to analyze the correlations of high expressions of micro ribonucleic acids (miRNAs) with traditional proteins and prognosis...

Correlations of high miRNA expressions with traditional proteins and prognosis of breast cancer

Published Online: Jul 31, 2024

Page range: 229 - 236

Received: Oct 26, 2023

Accepted: Apr 18, 2024

DOI: https://doi.org/10.2478/rrlm-2024-0018

Keywords
breast cancer, micro ribonucleic acid, prognosis, protein

© 2024 Jianrong Chen et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Correlations of high miRNA expressions with traditional proteins and prognosis of breast cancer

Published Online: Jul 31, 2024

Page range: 229 - 236

Received: Oct 26, 2023

Accepted: Apr 18, 2024

DOI: https://doi.org/10.2478/rrlm-2024-0018

Keywordsbreast cancer, micro ribonucleic acid, prognosis, protein

© 2024 Jianrong Chen et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
breast cancer, micro ribonucleic acid, prognosis, protein