<abstract xmlns="http://www.w3.org/1999/xhtml">

<bold>Introduction</bold>: Although pregnancy is a physiological condition, the secretion of diabetogenic hormones such as growth hormone, corticotropin-releasing hormone, placental lactogen hormone, prolactin and progesterone from the placenta could lead to insulin resistance (IR). In Metabolic Syndrome, obesity and Type1&amp;2 diabetes, a shift in the kynurenine pathway (KP) towards IDO activation is observed. The activation of the IDO leads to the activation of the Aryl hydrocarbon receptor (AhR) and Interleukin-6 (IL-6) also, which may also induce some effects like insulin resistance, β-cell disfunction and increased gluconeogenesis. We hypothesized that the overactivation of IDO and some KP enzymes would be observed in GDM patients, in a similar manner to metabolic syndrome, prediabetes, and diabetes patients.
<bold>Methods</bold>: 50 patients and 50 controls, who applied to the Endocrinology outpatient clinic of Selcuk University Faculty of Medicine were included. Serum triptophan metabolite levels were measured with liquid chromatography tandem mass spectrometry.
<bold>Results</bold>: Tryptophan and KYNA values was found to be lower in the patient group diagnosed with GDM (p&lt;0.001 and p&lt;0.001, respectively). The levels of KYN, 3-OH AA, 3-OH-KYN and KTR were significantly higher in the patient group compared to the control group (p=0.008, p&lt;0.001, p=0.05 and p&lt;0.001, respectively).
<bold>Conclusions</bold>: Understanding the changes that occur in this pathway in GDM patients may provide insight into the development of the disease. Also these tests could be used as supplementary tests in gestational diabetes, which could assist in diagnosis and patient follow-up.
</abstract>

Introduction: Although pregnancy is a physiological condition, the secretion of diabetogenic hormones such as growth hormone, corticotropin-releasing hormone, placental lactogen hormone, prolactin and progesterone from the placenta could lead to insulin resistance (IR). In Metabolic Syndrome, obesity and Type1&2 diabetes, a shift in the kynurenine pathway (KP) towards IDO activation is observed. The activation of the IDO leads to the activation of the Aryl hydrocarbon receptor (AhR) and Interleukin-6 (IL-6) also, which may also induce some effects like insulin resistance, β-cell disfunction and increased gluconeogenesis. We hypothesized that the overactivation of IDO and some KP enzymes would be observed in GDM patients, in a similar manner to metabolic syndrome, prediabetes, and diabetes patients.
Methods: 50 patients and 50 controls, who applied to the Endocrinology outpatient clinic of Selcuk University Faculty of Medicine were included. Serum triptophan metabolite levels were measured with liquid chromatography tandem mass spectrometry.
Results: Tryptophan and KYNA values was found to be lower in the patient group diagnosed with GDM (p<0.001 and p<0.001, respectively). The levels of KYN, 3-OH AA, 3-OH-KYN and KTR were significantly higher in the patient group compared to the control group (p=0.008, p<0.001, p=0.05 and p<0.001, respectively).
Conclusions: Understanding the changes that occur in this pathway in GDM patients may provide insight into the development of the disease. Also these tests could be used as supplementary tests in gestational diabetes, which could assist in diagnosis and patient follow-up.

Analyzing serum tryptophan metabolites in patients with gestational diabetes mellitus

Endocrinology, Selcuk University Medical Faculty

Selcuk University Vocational School of Health

Revista Romana de Medicina de Laborator

This work is licensed under the Creative Commons Attribution 4.0 International License.

Introduction: Although pregnancy is a physiological condition, the secretion of diabetogenic hormones such as growth hormone, corticotropin-releasing hormone,...

Analyzing serum tryptophan metabolites in patients with gestational diabetes mellitus

Published Online: Oct 28, 2023

Page range: 251 - 262

Received: Mar 12, 2023

Accepted: Sep 21, 2023

DOI: https://doi.org/10.2478/rrlm-2023-0027

Keywords
OGTT, gestational diabetes mellitus, tryptophan-kynurenine pathway

© 2023 Muammer Özdemir et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Analyzing serum tryptophan metabolites in patients with gestational diabetes mellitus

Published Online: Oct 28, 2023

Page range: 251 - 262

Received: Mar 12, 2023

Accepted: Sep 21, 2023

DOI: https://doi.org/10.2478/rrlm-2023-0027

KeywordsOGTT, gestational diabetes mellitus, tryptophan-kynurenine pathway

© 2023 Muammer Özdemir et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
OGTT, gestational diabetes mellitus, tryptophan-kynurenine pathway