<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Cardiac resynchronization therapy (CRT) was shown to greatly improve outcomes in specific patients with heart failure, low ejection fraction and wide QRS complex; however post-therapeutic response is heterogeneous and currently difficult to predict. There is an increasing interest in identifying humoral biomarkers which could help stratify prognosis, and better identify responders. The aim of this review was to provide an overview of recent data regarding the predictive value of biomarkers for evaluating response to CRT. A definitive conclusion cannot currently be drawn due to disparate results, varying methodologies, relatively small-scale studies and lack of consensus in defining CRT response. More extensive comparable research is paramount to facilitate progress in this field.</p>
</abstract>

Cardiac resynchronization therapy (CRT) was shown to greatly improve outcomes in specific patients with heart failure, low ejection fraction and wide QRS complex; however post-therapeutic response is heterogeneous and currently difficult to predict. There is an increasing interest in identifying humoral biomarkers which could help stratify prognosis, and better identify responders. The aim of this review was to provide an overview of recent data regarding the predictive value of biomarkers for evaluating response to CRT. A definitive conclusion cannot currently be drawn due to disparate results, varying methodologies, relatively small-scale studies and lack of consensus in defining CRT response. More extensive comparable research is paramount to facilitate progress in this field.

Updated insights into predictive biomarkers for response to cardiac resynchronization therapy - A literature review

George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures

Revista Romana de Medicina de Laborator

This work is licensed under the Creative Commons Attribution 4.0 International License.

Cardiac resynchronization therapy (CRT) was shown to greatly improve outcomes in specific patients with heart failure, low ejection fraction and wide QRS...

Updated insights into predictive biomarkers for response to cardiac resynchronization therapy - A literature review

Published Online: Oct 28, 2023

Page range: 225 - 240

Received: Aug 06, 2023

Accepted: Sep 13, 2023

DOI: https://doi.org/10.2478/rrlm-2023-0025

Keywords
biomarkers, cardiac resynchronization therapy, prediction

© 2023 Krisztina Pal et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Updated insights into predictive biomarkers for response to cardiac resynchronization therapy - A literature review

Published Online: Oct 28, 2023

Page range: 225 - 240

Received: Aug 06, 2023

Accepted: Sep 13, 2023

DOI: https://doi.org/10.2478/rrlm-2023-0025

Keywordsbiomarkers, cardiac resynchronization therapy, prediction

© 2023 Krisztina Pal et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
biomarkers, cardiac resynchronization therapy, prediction