Platelet index alterations in acute ST-elevation myocardial infarct: A retrospective pilot study

Introduction: Cardiovascular diseases (CVD) are responsible for approximately 17.9 millions of deaths every year, with a higher impact on low and middle-income populations. Despite traditional risk factors, asymptomatic individuals with atherosclerosis have been identified, and new biomarkers are being sought to better predict CVD risk. This study aims to investigate the relationship between platelets indices and biochemical variability in the first day after patient admission in the hospital.

Methods: A pilot study was conducted to analyze 73 medical records of patients who experienced acute myocardial infarction, to analyze the association among mean platelet volume (MPV), platelet count (PC), creatine phosphokinase (CPK), creatine phosphokinase-MB (CKMB) and ultra-sensitive cardiac troponin I (TnI-us) between the first and second sampling (1-hour intervals), to investigate acute ST-segment elevation myocardial infarction.

Results and conclusion: The biochemical analysis showed no significant difference in CPK CK MB, TnI-us, MPV and PC levels between the first and second samples. A negative correlation between PC and MPV and a moderate negative correlation between PC and CPK were found in our AMI patients within 24 hours of hospital admission.