<abstract xmlns="http://www.w3.org/1999/xhtml">

<bold>Objective</bold>: This study aimed to explore the diagnostic role of D-dimers and ferritin in ascitic fluid. We analyzed ascitic and blood samples from twenty cirrhotic patients, using the Child-Pugh classification to assess liver cirrhosis severity. Methods: Blood tests evaluated platelets, albumin, INR, fibrinogen, CRP, ferritin, and D-dimers, while ascitic fluid analysis incorporated total protein, albumin, LDH, cholesterol, leukocytes, with a focus on D-dimers and ferritin.
<bold>Results</bold>: The results showed a significant positive correlation between ascitic D-dimers and ferritin concentrations and ascitic albumin, total protein, and cholesterol. A correlation was also observed between ascitic ferritin and LDH. These correlations suggest a potential relationship between D-dimers and ferritin levels, disease severity, and the local production of these markers.
<bold>Conclusion</bold>: This study proposes that evaluating D-dimers and ferritin in ascitic fluid might reveal underlying inflammation, even when other inflammatory laboratory markers are normal. Our findings suggest that ascitic D-dimers and ferritin levels could offer valuable insights into inflammatory processes in ascitic fluid, potentially enhancing diagnostic and prognostic approaches for patients with ascites from liver cirrhosis or other causes. Further studies with larger and more diverse cohorts are needed to validate and extend our findings.
</abstract>

Objective: This study aimed to explore the diagnostic role of D-dimers and ferritin in ascitic fluid. We analyzed ascitic and blood samples from twenty cirrhotic patients, using the Child-Pugh classification to assess liver cirrhosis severity. Methods: Blood tests evaluated platelets, albumin, INR, fibrinogen, CRP, ferritin, and D-dimers, while ascitic fluid analysis incorporated total protein, albumin, LDH, cholesterol, leukocytes, with a focus on D-dimers and ferritin.
Results: The results showed a significant positive correlation between ascitic D-dimers and ferritin concentrations and ascitic albumin, total protein, and cholesterol. A correlation was also observed between ascitic ferritin and LDH. These correlations suggest a potential relationship between D-dimers and ferritin levels, disease severity, and the local production of these markers.
Conclusion: This study proposes that evaluating D-dimers and ferritin in ascitic fluid might reveal underlying inflammation, even when other inflammatory laboratory markers are normal. Our findings suggest that ascitic D-dimers and ferritin levels could offer valuable insights into inflammatory processes in ascitic fluid, potentially enhancing diagnostic and prognostic approaches for patients with ascites from liver cirrhosis or other causes. Further studies with larger and more diverse cohorts are needed to validate and extend our findings.

D-dimers and ferritin: Expanding the diagnostic panel for cirrhotic ascites evaluation

Department of Internal Medicine, Faculty of Medicine

Revista Romana de Medicina de Laborator

This work is licensed under the Creative Commons Attribution 4.0 International License.

Objective: This study aimed to explore the diagnostic role of D-dimers and ferritin in ascitic fluid. We analyzed ascitic and blood samples from twenty...

D-dimers and ferritin: Expanding the diagnostic panel for cirrhotic ascites evaluation

Published Online: Jul 28, 2023

Page range: 191 - 196

Received: Apr 20, 2023

Accepted: May 22, 2023

DOI: https://doi.org/10.2478/rrlm-2023-0016

Keywords
ascites, D- dimers, ferritin, inflammatory markers, hemostasis

© 2023 Petar Trifonov et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

D-dimers and ferritin: Expanding the diagnostic panel for cirrhotic ascites evaluation

Published Online: Jul 28, 2023

Page range: 191 - 196

Received: Apr 20, 2023

Accepted: May 22, 2023

DOI: https://doi.org/10.2478/rrlm-2023-0016

Keywordsascites, D- dimers, ferritin, inflammatory markers, hemostasis

© 2023 Petar Trifonov et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
ascites, D- dimers, ferritin, inflammatory markers, hemostasis