<abstract xmlns="http://www.w3.org/1999/xhtml">

<bold>Background</bold>: Acute kidney injury is a severe complication of COVID-19. Both COVID-19 and related acute kidney injury are reported in the literature to be more prevalent and more severe in males.
<bold>Methods</bold>: We performed a retrospective analysis of the COVID-19 associated acute kidney injury cases in order to search for differences between genders regarding patients’ and renal outcome.
<bold>Results</bold>: 250 patients with acute kidney injury were included in the study: 93 women (37.20%), 157 men (62.80%). There were no differences between sexes regarding age. Diabetes mellitus was significantly more present in women. Peak ferritin and procalcitonin levels were significantly higher in men, but other severity markers for COVID-19 did not differ between genders. There were no differences between sexes regarding history of chronic kidney disease, timing of acute kidney injury, need for dialysis or recovery of renal function. ICU admission and in-hospital mortality were similar between men and women.
<bold>Conclusions</bold>: In our study, COVID-19 related-AKI was more prevalent in men than in women, but the patients’ and renal outcome were similar. Significantly higher ferritin and procalcitonin serum levels registered in male patients when compared to women may have additional explanations beside more severe SARS-CoV-2 infection in males.
</abstract>

Background: Acute kidney injury is a severe complication of COVID-19. Both COVID-19 and related acute kidney injury are reported in the literature to be more prevalent and more severe in males.
Methods: We performed a retrospective analysis of the COVID-19 associated acute kidney injury cases in order to search for differences between genders regarding patients’ and renal outcome.
Results: 250 patients with acute kidney injury were included in the study: 93 women (37.20%), 157 men (62.80%). There were no differences between sexes regarding age. Diabetes mellitus was significantly more present in women. Peak ferritin and procalcitonin levels were significantly higher in men, but other severity markers for COVID-19 did not differ between genders. There were no differences between sexes regarding history of chronic kidney disease, timing of acute kidney injury, need for dialysis or recovery of renal function. ICU admission and in-hospital mortality were similar between men and women.
Conclusions: In our study, COVID-19 related-AKI was more prevalent in men than in women, but the patients’ and renal outcome were similar. Significantly higher ferritin and procalcitonin serum levels registered in male patients when compared to women may have additional explanations beside more severe SARS-CoV-2 infection in males.

Ferritin and procalcitonin in COVID-19 associated acute kidney injury – gender disparities, but similar outcomes

“Carol Davila” University of Medicine and Pharmacy Bucharest

Revista Romana de Medicina de Laborator

This work is licensed under the Creative Commons Attribution 4.0 International License.

Background: Acute kidney injury is a severe complication of COVID-19. Both COVID-19 and related acute kidney injury are reported in the literature to be more...

Ferritin and procalcitonin in COVID-19 associated acute kidney injury – gender disparities, but similar outcomes

Published Online: Feb 08, 2023

Page range: 35 - 42

Received: Oct 26, 2022

Accepted: Dec 27, 2022

DOI: https://doi.org/10.2478/rrlm-2023-0004

Keywords
acute kidney injury, gender, procalcitonin, ferritin, COVID-19

© 2023 Daniela Rădulescu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Ferritin and procalcitonin in COVID-19 associated acute kidney injury – gender disparities, but similar outcomes

Published Online: Feb 08, 2023

Page range: 35 - 42

Received: Oct 26, 2022

Accepted: Dec 27, 2022

DOI: https://doi.org/10.2478/rrlm-2023-0004

Keywordsacute kidney injury, gender, procalcitonin, ferritin, COVID-19

© 2023 Daniela Rădulescu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
acute kidney injury, gender, procalcitonin, ferritin, COVID-19