<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Objectives</bold>: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this study, we aimed to investigate the effects of resveratrol on the sphingosine-1-phosphate (S1P) and oxidative stress biomarkers in hearth ischemia-reperfusion (I/R).<bold>Materials and Methods</bold>: The biochemical and histopathological effects of RSV on cardiac ischemia-reperfusion injury were investigated through ELISA- and light microscope.<bold>Results</bold>: We observed statistically significant differences between the treatment group and the control group in terms of malondialdehyde (MDA) level, catalase (CAT) and superoxide dismutase (SOD) activities (p&lt;0.05). Histopathologically, we also observed decreased Polymorphonuclear Leucocyte (PMNL) infiltration, myocardial edema, miyositolysis in the treatment group compared to the I/R and sham groups.<bold>Conclusion</bold>: Resveratrol may play an important role in cardiac I/R injury through its anti-inflammatory and antioxidant effects which were biochemically and histopathologically confirmed in the present study.</abstract>

Objectives: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this study, we aimed to investigate the effects of resveratrol on the sphingosine-1-phosphate (S1P) and oxidative stress biomarkers in hearth ischemia-reperfusion (I/R).Materials and Methods: The biochemical and histopathological effects of RSV on cardiac ischemia-reperfusion injury were investigated through ELISA- and light microscope.Results: We observed statistically significant differences between the treatment group and the control group in terms of malondialdehyde (MDA) level, catalase (CAT) and superoxide dismutase (SOD) activities (p<0.05). Histopathologically, we also observed decreased Polymorphonuclear Leucocyte (PMNL) infiltration, myocardial edema, miyositolysis in the treatment group compared to the I/R and sham groups.Conclusion: Resveratrol may play an important role in cardiac I/R injury through its anti-inflammatory and antioxidant effects which were biochemically and histopathologically confirmed in the present study.

The Effect of Resveratrol on Sphingosine-1 and Oxidative/ Nitrosative Stress in an Experimental Heart Ischemia Reperfusion Model

Alanya Alaaddin Keykubat University, Faculty of Medicine

Kahramanmaras Sutcu Imam University, Faculty of Medicine

Department of Electronics-Automation Biomedical Device Technology Program

Harran University, Vocational School of Health Services

Revista Romana de Medicina de Laborator

This work is licensed under the Creative Commons Attribution 4.0 International License.

Objectives: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this study, we aimed to investigate the effects of...

The Effect of Resveratrol on Sphingosine-1 and Oxidative/ Nitrosative Stress in an Experimental Heart Ischemia Reperfusion Model

Published Online: Feb 12, 2022

Page range: 9 - 18

Received: May 25, 2021

Accepted: Oct 05, 2021

DOI: https://doi.org/10.2478/rrlm-2021-0036

Keywords
resveratrol, ischemia/reperfusion injury, antioxidant, oxidative stress, heart

© 2022 Seda Avnioglu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

The Effect of Resveratrol on Sphingosine-1 and Oxidative/ Nitrosative Stress in an Experimental Heart Ischemia Reperfusion Model

Published Online: Feb 12, 2022

Page range: 9 - 18

Received: May 25, 2021

Accepted: Oct 05, 2021

DOI: https://doi.org/10.2478/rrlm-2021-0036

Keywordsresveratrol, ischemia/reperfusion injury, antioxidant, oxidative stress, heart

© 2022 Seda Avnioglu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Keywords
resveratrol, ischemia/reperfusion injury, antioxidant, oxidative stress, heart