1. bookVolume 29 (2021): Issue 1 (January 2021)
Journal Details
License
Format
Journal
First Published
08 Aug 2013
Publication timeframe
4 times per year
Languages
English
access type Open Access

The Role of MiR-124 in Bladder Cancer – A Review of the Literature

Published Online: 29 Jan 2021
Page range: 9 - 18
Received: 30 Jun 2020
Accepted: 19 Nov 2020
Journal Details
License
Format
Journal
First Published
08 Aug 2013
Publication timeframe
4 times per year
Languages
English
Abstract

MicroRNAs (miRNAs) are a group of non-coding RNA molecules that have an important role in modulating the expression of genes involved in regulating cellular functions. A growing number of studies suggest the abnormal expression of microRNAs in different types of cancer cells. MiRNA-124 is a microRNA that is down-regulated in many types of cancer cells, including bladder cancer. Our objective is to provide a review of the key publications that studied the effect of miR-124 on bladder cancer. This review focus on the targets and different pathways of miR-124 that were identified in various studies and differences between their expressions in normal urothelium and tumor tissues. We also include data regarding urinary methylations levels of miR-124 and their role in bladder cancer diagnosis and prognosis. Subsequently, we establish future perspectives of miR-124 research and its promising role in bladder cancer.

Keywords

1. Globocan 2018, International Agency for Research on Cancer, World Health Organization, 2019 Jan. Available from http://gco.iarc.fr.Search in Google Scholar

2. Dyer T, Siemens DR, Nippak P, Meyer J, Booth CM. Histology at transurethral resection of bladder tumor and radical cystectomy for bladder cancer: Insights from population-based data. Can Urol Assoc J. 2020 Sep 28. DOI: 10.5489/cuaj.6856Search in Google Scholar

3. Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T. Identification of tissue-specific microRNAs from mouse. Curr Biol. 2002 Apr 30;12(9):735–9. DOI: 10.1016/S0960-9822(02)00809-6Search in Google Scholar

4. Ben Gacem R, Ben Abdelkrim O, Ziadi S, Ben Dhiab M, Trimeche M. Methylation of miR-124a-1, miR-124a-2, and miR-124a-3 genes correlates with aggressive and advanced breast cancer disease. Tumour Biol. 2014 May;35(5):4047–56. DOI: 10.1007/s13277-013-1530-4Search in Google Scholar

5. Chen ZY, Wang XY, Yang YM, Wu MH, Yang L, Jiang DT, Cai H, Peng Y. LncRNA SNHG16 promotes colorectal cancer cell proliferation, migration, and epithelial-mesenchymal transition through miR-124-3p/MCP-1. Gene Ther. 2020 Aug 28. DOI: 10.1038/s41434-020-0176-2Search in Google Scholar

6. Liu T, Zhu J, Du W, Ning W, Zhang Y, Zeng Y, Liu Z, Huang JA. AKT2 drives cancer progression and is negatively modulated by miR-124 in human lung adenocarcinoma. Respir Res. 2020 Sep 1;21(1):227. DOI: 10.1186/s12931-020-01491-0Search in Google Scholar

7. Yang T, Jin X, Lan J, Wang W. Long non-coding RNA SNHG16 has Tumor suppressing effect in acute lymphoblastic leukemia by inverse interaction on hsa-miR-124–3p. IUBMB Life. 2019 Jan;71(1):134–42. DOI: 10.1002/iub.1947Search in Google Scholar

8. Chen XX, Lin J, Qian J, Qian W, Yang J, Ma JC, et al. Dysregulation of miR-124-1 predicts favorable prognosis in acute myeloid leukemia. Clin Biochem. 2014 Jan;47(1–2):63–6. DOI: 10.1016/j.clinbiochem.2013.09.020Search in Google Scholar

9. Li Y, Yan J, Wang Y, Wang C, Zhang C, Li G. LINC00240 promotes gastric cancer cell proliferation, migration and EMT via the miR-124-3p / DNMT3B axis. Cell Biochem Funct. 2020;1–10.Search in Google Scholar

10. Moghadasi M, Alivand M, Fardi M, Moghadam KS, Solali S. Emerging molecular functions of microRNA-124: Cancer pathology and therapeutic implications. Pathol Res Pract. 2020 Mar;216(3):152827. DOI: 10.1016/j.prp.2020.152827Search in Google Scholar

11. Zo RB, Long Z.: MiR-124-3p suppresses bladder cancer by targeting DNA methyltransferase 3B. J Cell Physiol. 2018;1–11. DOI: 10.1002/jcp.26591Search in Google Scholar

12. Zhang T, Wang J, Chang J et al.: MiR-124 retards bladder cancer growth by directly targeting CDK4. Acta Biochim Biophys Sin (Shanghai) 2014 Dec;46(12):1072–9. DOI: 10.1093/abbs/gmu105Search in Google Scholar

13. Cao Z, Xu L, Zhao S, Zhu X. The functions of microRNA-124 on bladder cancer. Onco Targets Ther. 2019;12:3429–39. DOI: 10.2147/OTT.S193661Search in Google Scholar

14. Qu Y, Huang X, Li Z, Liu J, Wu J, Chen D, et al. miR-199a-3p inhibits aurora kinase A and attenuates prostate cancer growth: new avenue for prostate cancer treatment. Am J Pathol. 2014 May;184(5):1541–9. DOI: 10.1016/j.ajpath.2014.01.017Search in Google Scholar

15. Yuan Q, Sun T, Ye F, Kong W, Jin H. MicroRNA-124-3p affects proliferation, migration and apoptosis of bladder cancer cells through targeting AURKA. Cancer Bio-mark. 2017;19(1):93–101. DOI: 10.3233/CBM-160427Search in Google Scholar

16. Lombard AP, Mudryj M. The emerging role of the androgen receptor in bladder cancer. Endocrin Rel Cancer. 2015;22. DOI: 10.1530/ERC-15-0209Search in Google Scholar

17. Xiong Y, Wang L, Li Y, Chen M, He W, Qi L. The Long Non-Coding RNA XIST Interacted with MiR-124 to Modulate Bladder Cancer Growth, Invasion and Migration by Targeting Androgen Receptor (AR). Cell Physiol Biochem. 2017;43(1):405–18. DOI: 10.1159/000480419Search in Google Scholar

18. Wang JR, Liu B, Zhou L, Huang YX. MicroRNA-124-3p suppresses cell migration and invasion by targeting ITGA3 signaling in bladder cancer. Cancer Biomark. 2019;24(2):159–72. DOI: 10.3233/CBM-182000Search in Google Scholar

19. Wang X, Wu Q, Xu B, Wang P, Fan W, Cai Y, Gu X, Meng F. MiR-124 exerts tumor suppressive functions on the cell proliferation, motility and angiogenesis of bladder cancer by fine-tuning UHRF1. FEBS J. 2015 Nov;282(22):4376–88. DOI: 10.1111/febs.13502Search in Google Scholar

20. Zhou W, He L, Dai Y, Zhang Y, Wang J, Liu B. MicroRNA-124 inhibits cell proliferation, invasion and migration by targeting CAV1 in bladder cancer. Exp Ther Med. 2018 Oct;16(4):2811–20. DOI: 10.3892/etm.2018.6537Search in Google Scholar

21. Fu W, Wu X, Yang Z, Mi H. The effect of miR-124-3p on cell proliferation and apoptosis in bladder cancer by targeting EDNRB. Arch Med Sci. 2019 Sep;15(5):1154–62. DOI: 10.5114/aoms.2018.78743Search in Google Scholar

22. Jiao D, Li Z, Zhu M, Wang Y, Wu G, Han X. LncRNA MALAT1 promotes tumor growth and metastasis by targeting miR-124/foxq1 in bladder transitional cell carcinoma (BTCC). Am J Cancer Res. 2018;8(4):748–60.Search in Google Scholar

23. Xu X, Li S, Lin Y, Chen H, Hu Z, Mao Y, et al. MicroRNA-124-3p inhibits cell migration and invasion in bladder cancer cells by targeting ROCK1. J Transl Med. 2013 Nov 2;11:276. DOI: 10.1186/1479-5876-11-276Search in Google Scholar

24. Wang S, Wu G, Han Y, et al. miR-124 regulates STAT3-mediated cell proliferation, migration and apoptosis in bladder cancer. Oncol Lett. 2018;16(5):5875–81. DOI: 10.3892/ol.2018.9341Search in Google Scholar

25. Shimizu T, Suzuki H, Nojima M, et al. Methylation of a panel of microRNA genes is a novel biomarker for detection of bladder cancer. Eur Urol. 2013 Jun;63(6):1091–100. DOI: 10.1016/j.eururo.2012.11.030Search in Google Scholar

26. Shindo T, Shimizu T, Nojima M, Niinuma T, Maruyama R, Kitajima H, et al. Evaluation of Urinary DNA Methylation as a Marker for Recurrent Bladder Cancer: A 2-Center Prospective Study. Urology. 2018 Mar; 113:71–8. DOI: 10.1016/j.urology.2017.11.025Search in Google Scholar

27. Wang M, Meng B, Liu Y, Yu J, Chen Q, Liu Y. MiR-124 Inhibits Growth and Enhances Radiation-Induced Apoptosis in Non-Small Cell Lung Cancer by Inhibiting STAT3. Cell Physiol Biochem. 2017;44(5):2017–28. DOI: 10.1159/000485907Search in Google Scholar

28. Wang X, Li Y, Dai Y, Liu Q, Ning S,Liu J, et al. Sulforaphane improves chemotherapy efficacy by targeting cancer stem cell-like properties via the miR-124/IL-6R/STAT3 axis. 2016;Sci Rep 6:36796(2016). DOI: 10.1038/srep36796Search in Google Scholar

Recommended articles from Trend MD

Plan your remote conference with Sciendo