<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Background</bold>: Ovarian malignant germ cell tumors (OMGCT) that fail to recover with conventional management have a poor prognosis. Several recurrent events after chemotherapy have been found. Programmed death ligand-1 (PD-L1) is expressed in various malignancies and tumor infiltrating lymphocytes (TILs) with a known role as a prognostic factor.<bold>Objective</bold>: To determine the role of PD-L1 expression in OMGCT in determining overall survival (OS) and progression-free survival (PFS).<bold>Methods</bold>: Expression of PD-L1 was assessed from PD-L1 immunohisto-chemistry in paraffin block preparations from 40 patients diagnosed with OMGCT who met the inclusion criteria. The relationship between clinicopathological characteristics and OS and PFS was analyzed using the Kaplan-Meier method and multivariate analysis using the Cox regression model.<bold>Results</bold>: No significant relationship was found between PD-L1 expression in tumor cells with 2-year OS (p=0.275) and PFS (p=0.421) in OMGCT. A significant association was found between histopathologic types with 2-year OS (p=0.002), and cancer stage with 2- year OS (p=0.028) and PFS (p=0.014).<bold>Conclusion</bold>: PD-L1 expression in tumor cells was not related to OS and PFS in OMGCT patients. There is a tendency for death and recurrence in patients OMGCTs with low PD-L1 expression in tumor cells.</abstract>

Background: Ovarian malignant germ cell tumors (OMGCT) that fail to recover with conventional management have a poor prognosis. Several recurrent events after chemotherapy have been found. Programmed death ligand-1 (PD-L1) is expressed in various malignancies and tumor infiltrating lymphocytes (TILs) with a known role as a prognostic factor.Objective: To determine the role of PD-L1 expression in OMGCT in determining overall survival (OS) and progression-free survival (PFS).Methods: Expression of PD-L1 was assessed from PD-L1 immunohisto-chemistry in paraffin block preparations from 40 patients diagnosed with OMGCT who met the inclusion criteria. The relationship between clinicopathological characteristics and OS and PFS was analyzed using the Kaplan-Meier method and multivariate analysis using the Cox regression model.Results: No significant relationship was found between PD-L1 expression in tumor cells with 2-year OS (p=0.275) and PFS (p=0.421) in OMGCT. A significant association was found between histopathologic types with 2-year OS (p=0.002), and cancer stage with 2- year OS (p=0.028) and PFS (p=0.014).Conclusion: PD-L1 expression in tumor cells was not related to OS and PFS in OMGCT patients. There is a tendency for death and recurrence in patients OMGCTs with low PD-L1 expression in tumor cells.

The potential of programmed death ligand-1 expression in ovarian malignant germ cell tumors as a prognostic factor

Revista Romana de Medicina de Laborator

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Background: Ovarian malignant germ cell tumors (OMGCT) that fail to recover with conventional management have a poor prognosis. Several recurrent events after...

The potential of programmed death ligand-1 expression in ovarian malignant germ cell tumors as a prognostic factor

Published Online: Nov 18, 2020

Page range: 393 - 403

Received: Jun 16, 2020

Accepted: Sep 11, 2020

DOI: https://doi.org/10.2478/rrlm-2020-0032

Keywords
ovarian malignant germ cell tumors, tumor infiltrating lymphocytes, programmed death ligand-1, overall survival, progression-free survival

© 2020 Fadhlina Harahap et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The potential of programmed death ligand-1 expression in ovarian malignant germ cell tumors as a prognostic factor

Published Online: Nov 18, 2020

Page range: 393 - 403

Received: Jun 16, 2020

Accepted: Sep 11, 2020

DOI: https://doi.org/10.2478/rrlm-2020-0032

Keywordsovarian malignant germ cell tumors, tumor infiltrating lymphocytes, programmed death ligand-1, overall survival, progression-free survival

© 2020 Fadhlina Harahap et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
ovarian malignant germ cell tumors, tumor infiltrating lymphocytes, programmed death ligand-1, overall survival, progression-free survival