1. bookVolume 26 (2018): Issue 1 (January 2018)
Journal Details
License
Format
Journal
eISSN
2284-5623
First Published
08 Aug 2013
Publication timeframe
4 times per year
Languages
English
access type Open Access

Plasma phosphorylated neurofilament heavy chains as a potential marker for ischemic stroke patients

Published Online: 30 Jan 2018
Volume & Issue: Volume 26 (2018) - Issue 1 (January 2018)
Page range: 59 - 64
Received: 12 Dec 2017
Accepted: 10 Jan 2018
Journal Details
License
Format
Journal
eISSN
2284-5623
First Published
08 Aug 2013
Publication timeframe
4 times per year
Languages
English
Abstract

Background: The aim of the study was to determine the utility of plasma NfH in correlation with serum hsCRP for severity and short-term functional outcome prediction after ischemic stroke. Methods: 124 patients and 40 healthy controls were enrolled, serial plasma neurofilament heavy chains and hsCRP concentrations were measured and evaluated for TOAST subtype, stroke severity and functional outcome at discharge. Results: Serum level of hsCRP was significantly higher in patients versus controls (p<0.05) with no difference between TOAST subtypes. Plasma NfH concentration on day 5 was higher in CE stroke compared to LAA group and SVO group. A positive correlation between NfH levels on day 5 and mRS at discharge (r=0.304, p=0.001) and a gender stratification of hsCRP and mRS at discharge was found. Values of 6.04 mg/l for hsCRP and 46.4 ng/ml for NfH were found predictive for unfavorable short-term outcome, but after adjusting for age, sex and stroke severity, the prediction power was lost. Conclusions: Plasma concentration of NfH shows a significant increase over the first five days after ischemic stroke, in correlation with inflammatory status and short-term evolution.

Keywords

1. Glushakova O, Glushakov A, Miller E, Valadka A, Hayes R. Biomarkers for acute diagnosis and management of stroke in neurointensive care units. Brain Circ. 2016;2(1):28. DOI: 10.4103/2394-8108.17854610.4103/2394-8108.178546612624730276272Open DOISearch in Google Scholar

2. Hjalmarsson C, Bjerke M, Andersson B, Blennow K, Zetterberg H, Åberg ND, et al. Neuronal and Glia-Related Biomarkers in Cerebrospinal Fluid of Patients with Acute Ischemic Stroke. J Cent Nerv Syst Dis. 2014;6:51. DOI: 10.4137/JCNSD.S1382110.4137/JCNSD.S13821403929224932109Open DOISearch in Google Scholar

3. Ungureanu D, Iencean ŞM, Dimitriu C, Iencean AŞ, Tascu A. Determination of the phosphorylated neurofilament subunit NF-H (pNF-H) in cerebro-spinal fluid as biomarker in acute traumatic spinal cord injuries. Rev Rom Med Lab. 2014;22(3):377-86.Search in Google Scholar

4. Shaw G. Chapter 21 The Use and Potential of pNF-H as a General Blood Biomarker of Axonal. Brain Neurotrauma Mol Neuropsychol Rehabil Asp. 2015;1-17.Search in Google Scholar

5. Petzold A. Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss. J Neurol Sci. 2005;233(1):183-98. DOI: 10.1016/j.jns.2005.03.01510.1016/j.jns.2005.03.01515896809Open DOISearch in Google Scholar

6. Clark WM, Rinker LG, Lessov NS, Hazel K, Eckenstein F. Time course of IL-6 expression in experimental CNS ischemia. Neurol Res. 1999;21(3):287-92. DOI: 10.1080/01616412.1999.1174093310.1080/01616412.1999.1174093310319338Open DOISearch in Google Scholar

7. Adams HP, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993 ;24(1):35-41. DOI: 10.1161/01.STR.24.1.3510.1161/01.STR.24.1.357678184Open DOISearch in Google Scholar

8. Shibahashi K, Doi T, Tanaka S, Hoda H, Chikuda H, Sawada Y, et al. The Serum Phosphorylated Neurofilament Heavy Subunit as a Predictive Marker for Outcome in Adult Patients after Traumatic Brain Injury. J Neurotrauma. 2016;33(20):1826-33. DOI: 10.1089/neu.2015.423710.1089/neu.2015.423727098610Search in Google Scholar

9. Žurek J, Bartlová L, Fedora M. Hyperphosphorylated neurofilament NF-H as a predictor of mortality after brain injury in children. Brain Inj. 2011;25(2):221-6. DOI: 10.3109/02699052.2010.54189510.3109/02699052.2010.54189521219092Open DOISearch in Google Scholar

10. Cai JY, Lu C, Chen MH, Ba HJ, Chen XD, Lin JH, et al. Predictive value of phosphorylated axonal neurofilament subunit H for clinical outcome in patients with acute intracerebral hemorrhage. Clin Chim Acta. 2013;424:182-6. DOI: 10.1016/j.cca.2013.06.01910.1016/j.cca.2013.06.01923810564Search in Google Scholar

11. Traenka C, Disanto G, Seiffge DJ, Gensicke H, Hert L, Grond-Ginsbach C, et al. Serum Neurofilament Light Chain Levels Are Associated with Clinical Characteristics and Outcome in Patients with Cervical Artery Dissection. Cerebrovasc Dis. 2015;40(5-6):222-7. DOI: 10.1159/00044077410.1159/00044077426418549Open DOISearch in Google Scholar

12. Radwan WM, Rabbah AM, Saber H, Elghonemi MO. A new marker for ischemic cerebrovascular stroke: Phosphorylated Neurofilament H. Egypt J Crit Care Med. 2013;1(2):105-8. DOI: 10.1016/j.ejccm.2013.03.00410.1016/j.ejccm.2013.03.004Search in Google Scholar

13. Singh P, Yan J, Hull R, Read SJ, O’Sullivan J, Henderson RD, et al. Levels of phosphorylated axonal neurofilament subunit H (pNfH) are increased in acute ischemic stroke. J Neurol Sci. 2011;304(1-2):117-21. DOI: 10.1016/j.jns.2011.01.02510.1016/j.jns.2011.01.02521349546Open DOISearch in Google Scholar

14. Kim J-S, Lee K-B, Roh H, Ahn M-Y, Hwang H-W. Gender Differences in the Functional Recovery after Acute Stroke. J Clin Neurol. 2010;6(4):183. DOI: 10.3988/jcn.2010.6.4.18310.3988/jcn.2010.6.4.183302452221264198Open DOISearch in Google Scholar

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