<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Introduction: Methotrexate, a structural analogue to the folic acid, is one of the most frequently used antimetabolites in pediatric oncologic pathology. Its mode of action and toxic effects are now well known. Material </p><p>and method: Our study aimed to describe the quantitation of the drug in serum of 40 children with acute lymphatic leukemia receiving high doses of methotrexate and to predict serum methotrexate levels at 96 hours, based on 48 h, 72h levels and on alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea, and creatinine serum levels. The above mentioned parameters were analyzed by sampling serum levels at 48h, 72h and 96 hours after methotrexate administration and a logical regression model being projected upon obtained results. Results and conclusions: methotrexate serum level at 96 hours does not depend on either AST, ALT, urea, creatinine levels or on the methotrexate level determined at 48 hours, it only depends on the methotrexate serum level at 72 hours. </p></abstract>

Introduction: Methotrexate, a structural analogue to the folic acid, is one of the most frequently used antimetabolites in pediatric oncologic pathology. Its mode of action and toxic effects are now well known. Material and method: Our study aimed to describe the quantitation of the drug in serum of 40 children with acute lymphatic leukemia receiving high doses of methotrexate and to predict serum methotrexate levels at 96 hours, based on 48 h, 72h levels and on alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea, and creatinine serum levels. The above mentioned parameters were analyzed by sampling serum levels at 48h, 72h and 96 hours after methotrexate administration and a logical regression model being projected upon obtained results. Results and conclusions: methotrexate serum level at 96 hours does not depend on either AST, ALT, urea, creatinine levels or on the methotrexate level determined at 48 hours, it only depends on the methotrexate serum level at 72 hours.

Mathematical model to predict methotrexate elimination in children with acute lymphoblastic leukemia

University of Medicine and Pharmacy “Grigore T. Popa”, Iași / Institute of Cardio-vascular Diseases “Prof. Dr. G. Georgescu”, Iași

University of Medicine and Pharmacy “Grigore T. Popa”, Iași / “Sfânta Maria” Emergency Children’s Hospital, Iași

University of Medicine and Pharmacy “Grigore T. Popa”, Iași / Regional Oncology Institute, Iași

Revista Romana de Medicina de Laborator

Introduction: Methotrexate, a structural analogue to the folic acid, is one of the most frequently used antimetabolites in pediatric oncologic pathology. Its...

Mathematical model to predict methotrexate elimination in children with acute lymphoblastic leukemia

Published Online: Mar 25, 2014

Page range: 101 - 109

DOI: https://doi.org/10.2478/rrlm-2014-0012

Keywords
methotrexate serum level, toxicity

This content is open access.

Mathematical model to predict methotrexate elimination in children with acute lymphoblastic leukemia

Published Online: Mar 25, 2014

Page range: 101 - 109

DOI: https://doi.org/10.2478/rrlm-2014-0012

Keywordsmethotrexate serum level, toxicity

This content is open access.

Keywords
methotrexate serum level, toxicity