<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Hepatitis C virus is known to be a risk factor for the development of B-cell non-Hodgkin lymphoma. Studies investigating the prevalence of hepatitis C virus in lymphoma report controversial results, depending on the geographical area. Monoclonal B lymphocytosis is an asymptomatic condition which can evolve into malignant lymphoma, characterized by the presence of a circulating clonal B population. It can be detected by flow cytometry and it is found at higher prevalence in hepatitis C virus-infected patients than in the general population. In the literature, there are only a few studies investigating its prevalence in hepatitis C infected patients and in Romania, such a study hasn’t been carried out before. We conducted a prospective study on 50 hepatitis C virus-infected patients from the Regional Institute of Gastroenterology and Hepatology Prof. Dr. Octavian Fodor. Clinical and laboratory data were collected from the medical files. Flow cytometric analysis was carried out at the Immunology Department of the Emergency County Hospital Cluj Napoca. We have found a prevalence of 22% of monoclonal B lymphocytosis. There were no statistical differences between patients with or without monoclonality, except for the lower leucocyte count (p=0.04) and the more increased liver echogenicity in patients with monoclonality (p=0.02). All of the 3 subtypes of monoclonal B lymphocytosis were found. Increased prevalence of monoclonal B lymphocytosis in patients with hepatitis C virus infection sustains the virus role in lymphomagenesis, but further studies are needed to analyze the rate of transformation into lymphoma in these patients.</p></abstract>

Hepatitis C virus is known to be a risk factor for the development of B-cell non-Hodgkin lymphoma. Studies investigating the prevalence of hepatitis C virus in lymphoma report controversial results, depending on the geographical area. Monoclonal B lymphocytosis is an asymptomatic condition which can evolve into malignant lymphoma, characterized by the presence of a circulating clonal B population. It can be detected by flow cytometry and it is found at higher prevalence in hepatitis C virus-infected patients than in the general population. In the literature, there are only a few studies investigating its prevalence in hepatitis C infected patients and in Romania, such a study hasn’t been carried out before. We conducted a prospective study on 50 hepatitis C virus-infected patients from the Regional Institute of Gastroenterology and Hepatology Prof. Dr. Octavian Fodor. Clinical and laboratory data were collected from the medical files. Flow cytometric analysis was carried out at the Immunology Department of the Emergency County Hospital Cluj Napoca. We have found a prevalence of 22% of monoclonal B lymphocytosis. There were no statistical differences between patients with or without monoclonality, except for the lower leucocyte count (p=0.04) and the more increased liver echogenicity in patients with monoclonality (p=0.02). All of the 3 subtypes of monoclonal B lymphocytosis were found. Increased prevalence of monoclonal B lymphocytosis in patients with hepatitis C virus infection sustains the virus role in lymphomagenesis, but further studies are needed to analyze the rate of transformation into lymphoma in these patients.

Monoclonal B cell lymphocytosis in patients with hepatitis C virus infection: prevalence, demographic and laboratory correlations

The Oncology Institute Prof. Dr. Ion Chiricuţă - Hematology Department, Bd. 21 Decembrie nr.73, Cluj-Napoca, Tel.: 0729929275

Emergency County Hospital Cluj-Napoca - Immunology Department

The Oncology Institute Prof. Dr. Ion Chiricuţă - Hematology Department

Regional Institute of Hepatology and Gastroenterology Prof. Dr. Octavian Fodor

Revista Romana de Medicina de Laborator

Hepatitis C virus is known to be a risk factor for the development of B-cell non-Hodgkin lymphoma. Studies investigating the prevalence of hepatitis C virus in...

Monoclonal B cell lymphocytosis in patients with hepatitis C virus infection: prevalence, demographic and laboratory correlations

Published Online: Jun 21, 2013

Page range: 209 - 215

DOI: https://doi.org/10.2478/rrlm-2013-0007

This content is open access.