<abstract xmlns="http://www.w3.org/1999/xhtml">

Gonarthrosis is one of the main causes of pain and limitation of physical activity in elderly patients. The diagnosis is established based on the clinical and radiological examination, and the treatment consists of non-surgical measures. The final stage of gonarthrosis is treated surgically and consists of total knee arthroplasty.
The molecular study in gonarthrosis aims to identify patients with early stages of arthrosis, with reversible potential, who can benefit from etiological treatment and non-pharmacological measures to slow down the evolution of the disease or even reversibility. Total knee arthroplasty is a surgical intervention with the role of reducing the symptoms and restoring the functionality of the affected joint.
Total knee arthroplasty remains the surgical intervention of choice in the case of patients in the final stage of the evolution of the disease with very good functional outcome.
</abstract>

Gonarthrosis is one of the main causes of pain and limitation of physical activity in elderly patients. The diagnosis is established based on the clinical and radiological examination, and the treatment consists of non-surgical measures. The final stage of gonarthrosis is treated surgically and consists of total knee arthroplasty.
The molecular study in gonarthrosis aims to identify patients with early stages of arthrosis, with reversible potential, who can benefit from etiological treatment and non-pharmacological measures to slow down the evolution of the disease or even reversibility. Total knee arthroplasty is a surgical intervention with the role of reducing the symptoms and restoring the functionality of the affected joint.
Total knee arthroplasty remains the surgical intervention of choice in the case of patients in the final stage of the evolution of the disease with very good functional outcome.

Gene expression and molecular aspects in osteoarthritis of the knee - review of literature

Orthopaedic Surgery and Traumatology Department

“Carol Davila” University of Medicine and Pharmacy

Romanian Journal of Orthopaedic Surgery and Traumatology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Gonarthrosis is one of the main causes of pain and limitation of physical activity in elderly patients. The diagnosis is established based on the clinical and...

Gene expression and molecular aspects in osteoarthritis of the knee - review of literature

Published Online: Dec 21, 2022

Page range: 35 - 41

Accepted: Dec 08, 2022

DOI: https://doi.org/10.2478/rojost-2022-0007

Keywords
knee osteoarthritis, gene expression, molecular, review

© 2022 Sergiu Andrei Iordache et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Gene expression and molecular aspects in osteoarthritis of the knee - review of literature

Published Online: Dec 21, 2022

Page range: 35 - 41

Accepted: Dec 08, 2022

DOI: https://doi.org/10.2478/rojost-2022-0007

Keywordsknee osteoarthritis, gene expression, molecular, review

© 2022 Sergiu Andrei Iordache et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
knee osteoarthritis, gene expression, molecular, review