<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Sinonasal malignant melanoma is a rare, aggressive tumor, associated with a poor prognosis, accounting for 8-15% of all head and neck melanomas and 0.5-2% of all melanomas. The diagnosis is given by histopathological and immunological examination. Elective treatment consists of surgical excision with free resection borders, and adjuvant chemotherapy / radiotherapy / immunotherapy / checkpoint inhibitors can be used to control local recurrence and distant metastases. We chose to present the case of an unresectable ethmoidal malignant melanoma at the time of diagnosis, pembrolizumab treatment converting it to resectability, with improving patient’s quality of life, even if the patient developed an adrenal metastasis.</p>
</abstract>

Sinonasal malignant melanoma is a rare, aggressive tumor, associated with a poor prognosis, accounting for 8-15% of all head and neck melanomas and 0.5-2% of all melanomas. The diagnosis is given by histopathological and immunological examination. Elective treatment consists of surgical excision with free resection borders, and adjuvant chemotherapy / radiotherapy / immunotherapy / checkpoint inhibitors can be used to control local recurrence and distant metastases. We chose to present the case of an unresectable ethmoidal malignant melanoma at the time of diagnosis, pembrolizumab treatment converting it to resectability, with improving patient’s quality of life, even if the patient developed an adrenal metastasis.

Sinonasal malignant melanoma

“Iuliu Hatieganu” University of Medicine and Pharmacy

Romanian Journal of Rhinology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Sinonasal malignant melanoma"}

Sinonasal malignant melanoma is a rare, aggressive tumor, associated with a poor prognosis, accounting for 8-15% of all head and neck melanomas and 0.5-2% of...

Sinonasal malignant melanoma

Published Online: Jul 18, 2022

Page range: 135 - 139

Received: Apr 10, 2022

Accepted: May 19, 2022

DOI: https://doi.org/10.2478/rjr-2022-0020

Keywords
melanoma, sinonasal, ethmoid, unresectable, pembrolizumab

© 2022 Daiana Birta et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Sinonasal malignant melanoma

Published Online: Jul 18, 2022

Page range: 135 - 139

Received: Apr 10, 2022

Accepted: May 19, 2022

DOI: https://doi.org/10.2478/rjr-2022-0020

Keywordsmelanoma, sinonasal, ethmoid, unresectable, pembrolizumab

© 2022 Daiana Birta et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
melanoma, sinonasal, ethmoid, unresectable, pembrolizumab