<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Recurrent laryngeal papillomatosis is a disease caused by human papillomaviruses (HPVs), which currently does not benefit from a curative treatment. Due to the fact that HPV has the action of modifying cellular DNA, with changes in the expression of interleukins and interferon, with insufficient maturation of T cells and intracellular overpopulation of immunosuppressive cells, the association of RRP (Recurrent Respiratory Papillomatosis) with an autoimmune disease may cause particular difficulties in the therapeutic management of patients diagnosed with RRP.</p><p>Immunosuppressive medication negatively influences the development of papillomatosis, increasing the number of local relapses and, respectively, the need for surgical intervention due to the increased viral multiplication and the proliferation of papillomatous lesions. In order to exemplify the difficulties encountered in treating RRP associated with an autoimmune disorder, the authors present the case of a 21-year-old patient diagnosed with juvenile recurrent laryngeal papillomatosis genotype 6, with multiple antecedent surgeries, who was diagnosed with pemphigus vulgaris at the age of 19. The peculiarity of the case lies in the difficulty of managing the RRP associated with an immunosuppressive disorder whose therapeutic indication is cortisone and immunosuppressive treatment, which led to exacerbation of viral multiplication and proliferation of papillomatous lesions.</p></abstract>

Recurrent laryngeal papillomatosis is a disease caused by human papillomaviruses (HPVs), which currently does not benefit from a curative treatment. Due to the fact that HPV has the action of modifying cellular DNA, with changes in the expression of interleukins and interferon, with insufficient maturation of T cells and intracellular overpopulation of immunosuppressive cells, the association of RRP (Recurrent Respiratory Papillomatosis) with an autoimmune disease may cause particular difficulties in the therapeutic management of patients diagnosed with RRP.Immunosuppressive medication negatively influences the development of papillomatosis, increasing the number of local relapses and, respectively, the need for surgical intervention due to the increased viral multiplication and the proliferation of papillomatous lesions. In order to exemplify the difficulties encountered in treating RRP associated with an autoimmune disorder, the authors present the case of a 21-year-old patient diagnosed with juvenile recurrent laryngeal papillomatosis genotype 6, with multiple antecedent surgeries, who was diagnosed with pemphigus vulgaris at the age of 19. The peculiarity of the case lies in the difficulty of managing the RRP associated with an immunosuppressive disorder whose therapeutic indication is cortisone and immunosuppressive treatment, which led to exacerbation of viral multiplication and proliferation of papillomatous lesions.

Difficulties in the treatment of recurrent juvenile laryngeal papillomatosis associated with pemphigus vulgaris

“Carol Davila” University of Medicine and Pharmacy

“Prof. Dr. D. Hociota” Institute of Phono-Audiology and Functional Surgery

Romanian Journal of Rhinology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Recurrent laryngeal papillomatosis is a disease caused by human papillomaviruses (HPVs), which currently does not benefit from a curative treatment. Due to the...

Difficulties in the treatment of recurrent juvenile laryngeal papillomatosis associated with pemphigus vulgaris

Published Online: Apr 24, 2020

Page range: 38 - 44

Received: Jan 06, 2020

Accepted: Feb 14, 2020

DOI: https://doi.org/10.2478/rjr-2020-0009

Keywords
recurrent respiratory papillomatosis, cidofovir, human papillomavirus, pemphigus vulgaris, immunosuppressive disorder

© 2020 Codrut Sarafoleanu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Difficulties in the treatment of recurrent juvenile laryngeal papillomatosis associated with pemphigus vulgaris

Published Online: Apr 24, 2020

Page range: 38 - 44

Received: Jan 06, 2020

Accepted: Feb 14, 2020

DOI: https://doi.org/10.2478/rjr-2020-0009

Keywordsrecurrent respiratory papillomatosis, cidofovir, human papillomavirus, pemphigus vulgaris, immunosuppressive disorder

© 2020 Codrut Sarafoleanu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
recurrent respiratory papillomatosis, cidofovir, human papillomavirus, pemphigus vulgaris, immunosuppressive disorder