<abstract xmlns="http://www.w3.org/1999/xhtml">

Background: Metabolic-associated fatty liver disease and liver fibrosis are intimately linked to insulin resistance, type 2 diabetes, obesity, and metabolic syndrome. Transient elastography (TE) and point shear wave elastography (pSWE) were used to measure liver stiffness in patients who met the ultrasound criteria for steatotic liver diseases (SLD). This study compared two methods for estimating liver stiffness in patients with SLD, which in turn correlated with liver fibrosis. Method: Ultrasound B-mode imaging was used to identify SLD. In total, 250 MAFLD patients were recruited. Patient characteristics, laboratory investigations, and liver stiffness measurements using TE and pSWE were assessed on the same day.
Results: In the study, 56.0% of the patients were male, with a mean age of 41.5 ± 10.7 years. The correlation between TE and pSWE was significant (Spearman’s r = 0.867*, p &lt; .001). The Bland-Altman Plot analysis confirmed this, with 97.5% of variations in LSM falling within 95% agreement ranges. Cohen’s κ was used to assess the agreement between TE and pSWE fibrosis stages, showing almost perfect agreement (83.5% kappa agreement) and a strong association between pSWE and TE in the assessment fibrosis stages.
Conclusion: In patients with MAFLD, TE, and SWE are reliable methods for measuring liver stiffness and can be used as non-invasive screening tools for the assessment of fibrosis in SLD.
</abstract>

Background: Metabolic-associated fatty liver disease and liver fibrosis are intimately linked to insulin resistance, type 2 diabetes, obesity, and metabolic syndrome. Transient elastography (TE) and point shear wave elastography (pSWE) were used to measure liver stiffness in patients who met the ultrasound criteria for steatotic liver diseases (SLD). This study compared two methods for estimating liver stiffness in patients with SLD, which in turn correlated with liver fibrosis. Method: Ultrasound B-mode imaging was used to identify SLD. In total, 250 MAFLD patients were recruited. Patient characteristics, laboratory investigations, and liver stiffness measurements using TE and pSWE were assessed on the same day.
Results: In the study, 56.0% of the patients were male, with a mean age of 41.5 ± 10.7 years. The correlation between TE and pSWE was significant (Spearman’s r = 0.867*, p < .001). The Bland-Altman Plot analysis confirmed this, with 97.5% of variations in LSM falling within 95% agreement ranges. Cohen’s κ was used to assess the agreement between TE and pSWE fibrosis stages, showing almost perfect agreement (83.5% kappa agreement) and a strong association between pSWE and TE in the assessment fibrosis stages.
Conclusion: In patients with MAFLD, TE, and SWE are reliable methods for measuring liver stiffness and can be used as non-invasive screening tools for the assessment of fibrosis in SLD.

Comparison of transient elastography and shear wave elastography in patients with MAFLD: A single-center experience

Department of Hepatology and Gastroenterology, National Liver Institute

Department of Diagnostic and Interventional Radiology and Medical Imaging, National Liver Institute

Department of Epidemiology and Preventive Medicine, National Liver Institute

st. Joseph University Medical Center is affiliated with Rowan University

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Background: Metabolic-associated fatty liver disease and liver fibrosis are intimately linked to insulin resistance, type 2 diabetes, obesity, and metabolic...

Comparison of transient elastography and shear wave elastography in patients with MAFLD: A single-center experience

Published Online: Apr 24, 2024

Page range: -

Received: Feb 03, 2024

DOI: https://doi.org/10.2478/rjim-2024-0019

Keywords
Metabolic-associated fatty liver diseases (MAFLD), Point shear wave elastography (SWE), Transient elastography (TE), Liver stiffness measurement, Liver fibrosis, NAFLD

© 2024 Mohamed Ahmed Samy Kohla et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Comparison of transient elastography and shear wave elastography in patients with MAFLD: A single-center experience

Published Online: Apr 24, 2024

Page range: -

Received: Feb 03, 2024

DOI: https://doi.org/10.2478/rjim-2024-0019

KeywordsMetabolic-associated fatty liver diseases (MAFLD), Point shear wave elastography (SWE), Transient elastography (TE), Liver stiffness measurement, Liver fibrosis, NAFLD

© 2024 Mohamed Ahmed Samy Kohla et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Metabolic-associated fatty liver diseases (MAFLD), Point shear wave elastography (SWE), Transient elastography (TE), Liver stiffness measurement, Liver fibrosis, NAFLD