<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Hydroxychloroquine (HCQ) induced cardiotoxicity is a rare diagnosis and is often associated with chronic use of the medication. It has been shown that chronic HCQ use is associated with a drug-induced cardiomyopathy mainly driven by acquired lysosomal storage defects leading to hypertrophy and conduction abnormalities. As the only proven treatment is the discontinuation of the offending agent, prompt recognition is required to avoid further exposure to the drug and potential progression of disease. History, physical examination and advanced imaging modalities are useful diagnostic tools, but more invasive testing with an endomyocardial biopsy is required for definitive diagnosis. We present a descriptive case series of ten patients that were diagnosed with biopsy proven HCQ cardiotoxicity.</p>
</abstract>

Hydroxychloroquine (HCQ) induced cardiotoxicity is a rare diagnosis and is often associated with chronic use of the medication. It has been shown that chronic HCQ use is associated with a drug-induced cardiomyopathy mainly driven by acquired lysosomal storage defects leading to hypertrophy and conduction abnormalities. As the only proven treatment is the discontinuation of the offending agent, prompt recognition is required to avoid further exposure to the drug and potential progression of disease. History, physical examination and advanced imaging modalities are useful diagnostic tools, but more invasive testing with an endomyocardial biopsy is required for definitive diagnosis. We present a descriptive case series of ten patients that were diagnosed with biopsy proven HCQ cardiotoxicity.

Hydroxychloroquine Induced Cardiotoxicity: A Case Series

Department of Quantitative Health Science

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Hydroxychloroquine Induced Cardiotoxicity: A Case Series"}

Hydroxychloroquine (HCQ) induced cardiotoxicity is a rare diagnosis and is often associated with chronic use of the medication. It has been shown that chronic...

Hydroxychloroquine Induced Cardiotoxicity: A Case Series

Published Online: Feb 20, 2024

Page range: 210 - 215

Received: Jan 30, 2024

DOI: https://doi.org/10.2478/rjim-2024-0005

Keywords
Hydroxychlorquine, drug toxicity, cardiomyopathy, systemic lupus erythematous, rheumatoid arthritis, Sjögren’s syndrome

© 2024 Artur Schneider et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Hydroxychloroquine Induced Cardiotoxicity: A Case Series

Published Online: Feb 20, 2024

Page range: 210 - 215

Received: Jan 30, 2024

DOI: https://doi.org/10.2478/rjim-2024-0005

KeywordsHydroxychlorquine, drug toxicity, cardiomyopathy, systemic lupus erythematous, rheumatoid arthritis, Sjögren’s syndrome

© 2024 Artur Schneider et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Hydroxychlorquine, drug toxicity, cardiomyopathy, systemic lupus erythematous, rheumatoid arthritis, Sjögren’s syndrome