<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Carcinomatosis of the bone marrow is a rare clinical condition characterized by diffuse tumor infiltration of the bone marrow accompanied by hematological abnormalities, including thrombotic microangiopathy (TMA) and disseminated intravascular coagulation (DIC). In patients with gastric carcinoma, this association is infrequent. Below we present a case of a 19-year-old female patient with no known pathological history who presented with upper digestive tract bleeding. Upon examination, anemia and thrombocytopenia were documented, with schistocytes in the peripheral blood smear and prolonged coagulation times.</p>
<p>Endoscopic studies indicated a lesion in the Borrmann IV gastric body, and the bone marrow biopsy showed the presence of signet ring cells. Because there was no possibility of systemic therapy, the patient died during hospitalization. This case contributes to the medical literature by describing an unusual presentation of a very frequent pathology.</p>
</abstract>

Carcinomatosis of the bone marrow is a rare clinical condition characterized by diffuse tumor infiltration of the bone marrow accompanied by hematological abnormalities, including thrombotic microangiopathy (TMA) and disseminated intravascular coagulation (DIC). In patients with gastric carcinoma, this association is infrequent. Below we present a case of a 19-year-old female patient with no known pathological history who presented with upper digestive tract bleeding. Upon examination, anemia and thrombocytopenia were documented, with schistocytes in the peripheral blood smear and prolonged coagulation times.
Endoscopic studies indicated a lesion in the Borrmann IV gastric body, and the bone marrow biopsy showed the presence of signet ring cells. Because there was no possibility of systemic therapy, the patient died during hospitalization. This case contributes to the medical literature by describing an unusual presentation of a very frequent pathology.

Thrombotic microangiopathy and disseminated intravascular coagulation in a patient with carcinomatosis of the bone marrow due to gastric adenocarcinoma: Case report

Associate Professor. Department of Internal Medicine. Faculty of Medicine

Assistant Professor. Department of Internal Medicine. Faculty of Medicine

Associate Professor. Department of Pathology. Faculty of Medicine

Medical Student, Pontificia Universidad Javeriana

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Carcinomatosis of the bone marrow is a rare clinical condition characterized by diffuse tumor infiltration of the bone marrow accompanied by hematological...

Thrombotic microangiopathy and disseminated intravascular coagulation in a patient with carcinomatosis of the bone marrow due to gastric adenocarcinoma: Case report

Published Online: Jun 30, 2023

Page range: 167 - 174

Received: Apr 20, 2023

DOI: https://doi.org/10.2478/rjim-2023-0015

Keywords
Disseminated intravascular coagulation, gastric cancer, Bone marrow diseases, signet ring cells, thrombotic microangiopathy

© 2023 Gabriel Suarez-Reyes et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Thrombotic microangiopathy and disseminated intravascular coagulation in a patient with carcinomatosis of the bone marrow due to gastric adenocarcinoma: Case report

Published Online: Jun 30, 2023

Page range: 167 - 174

Received: Apr 20, 2023

DOI: https://doi.org/10.2478/rjim-2023-0015

KeywordsDisseminated intravascular coagulation, gastric cancer, Bone marrow diseases, signet ring cells, thrombotic microangiopathy

© 2023 Gabriel Suarez-Reyes et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Disseminated intravascular coagulation, gastric cancer, Bone marrow diseases, signet ring cells, thrombotic microangiopathy