<abstract xmlns="http://www.w3.org/1999/xhtml">

<bold>Objective:</bold> Obesity is a worldwide concern that may lead to type 2 diabetes, cardiovascular diseases, etc. Several serum biomarkers have been identified in the saliva of obese individuals, including inflammatory cytokines, adipokines, insulin, and cortisol. The present study aimed to compare salivary interleukin-6 (IL-6), interleukin-8 (IL-8), C-reactive protein (CRP) levels and total antioxidants capacity (TAC) of obese individuals with normal-weighted ones.
<bold>Methods:</bold> In this case–control study, 92 participants matched in terms of age and gender were placed into two groups according to the body mass index (BMI); case group: BMI>30 and control group: 18.5&lt;BMI&lt;24.99. Unstimulated saliva was collected. ELISA and FRAP method were used to determine IL-6, IL-8, CRP and TAC. Data was analyzed using SPSS 24, at the significant level of 0.05.
<bold>Results:</bold> Mean salivary levels of IL-6 and IL-8 in the normal individuals were 53.36 and 421.25ng/mL, with 86.09 ng/mL and 510.19 ng/mL in obese individuals, respectively. There were significant differences in the mean salivary levels of IL-6 and IL-8 between two experimental groups.
The mean salivary levels of CRP of control and case group was 2.84 and 2.63 ng/mL and the total salivary antioxidant levels in the normal and obese individuals were 0.29 and 0.36, respectively which had no significant different.
<bold>Conclusion:</bold> According to the results of the present study, salivary levels IL-8 and IL-6 was significantly higher in obese individuals than in those with normal weight. However, the mean salivary CRP and TAC were not significantly different between the obese individuals and normal-weighted ones.
</abstract>

Objective: Obesity is a worldwide concern that may lead to type 2 diabetes, cardiovascular diseases, etc. Several serum biomarkers have been identified in the saliva of obese individuals, including inflammatory cytokines, adipokines, insulin, and cortisol. The present study aimed to compare salivary interleukin-6 (IL-6), interleukin-8 (IL-8), C-reactive protein (CRP) levels and total antioxidants capacity (TAC) of obese individuals with normal-weighted ones.
Methods: In this case–control study, 92 participants matched in terms of age and gender were placed into two groups according to the body mass index (BMI); case group: BMI>30 and control group: 18.5<BMI<24.99. Unstimulated saliva was collected. ELISA and FRAP method were used to determine IL-6, IL-8, CRP and TAC. Data was analyzed using SPSS 24, at the significant level of 0.05.
Results: Mean salivary levels of IL-6 and IL-8 in the normal individuals were 53.36 and 421.25ng/mL, with 86.09 ng/mL and 510.19 ng/mL in obese individuals, respectively. There were significant differences in the mean salivary levels of IL-6 and IL-8 between two experimental groups.
The mean salivary levels of CRP of control and case group was 2.84 and 2.63 ng/mL and the total salivary antioxidant levels in the normal and obese individuals were 0.29 and 0.36, respectively which had no significant different.
Conclusion: According to the results of the present study, salivary levels IL-8 and IL-6 was significantly higher in obese individuals than in those with normal weight. However, the mean salivary CRP and TAC were not significantly different between the obese individuals and normal-weighted ones.

Comparison of salivary interleukin-6, interleukin-8, C - reactive protein levels and total antioxidants capacity of obese individuals with normal-weight ones

Dental student, Department of Oral and Maxillofacial Medicine

Assistant Professor, Department of Oral and Maxillofacial Medicine

Professor, Department of Oral and Maxillofacial Medicine

Associate Professor, Department of Biostatistics

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Objective: Obesity is a worldwide concern that may lead to type 2 diabetes, cardiovascular diseases, etc. Several serum biomarkers have been identified in the...

Comparison of salivary interleukin-6, interleukin-8, C - reactive protein levels and total antioxidants capacity of obese individuals with normal-weight ones

Published Online: Nov 23, 2022

Page range: 215 - 221

Received: May 06, 2022

DOI: https://doi.org/10.2478/rjim-2022-0013

Keywords
obesity, C-reactive protein, interleukin-6, interleukin-8, antioxidants, saliva, obesity markers

© 2022 Deniz Safabakhsh et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Comparison of salivary interleukin-6, interleukin-8, C - reactive protein levels and total antioxidants capacity of obese individuals with normal-weight ones

Published Online: Nov 23, 2022

Page range: 215 - 221

Received: May 06, 2022

DOI: https://doi.org/10.2478/rjim-2022-0013

Keywordsobesity, C-reactive protein, interleukin-6, interleukin-8, antioxidants, saliva, obesity markers

© 2022 Deniz Safabakhsh et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
obesity, C-reactive protein, interleukin-6, interleukin-8, antioxidants, saliva, obesity markers