<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>A 59-year-old man who had smoked for 23 pack-years was admitted to our hospital because of two-month history of back pain. The chest computed tomography scan demonstrated combined pulmonary fibrosis and emphysema (CPFE) and an irregular shaped nodule in the left lower lobe of the lung. A biopsy obtained from samples from subcarinal lymph nodes revealed non-small cell lung cancer. Anti-aminoacyl-tRNA synthetase (ARS) antibody was elevated up to 166 U/mL, although he had no symptoms suggestive connective tissue diseases. It is well known that most of CPFE patients are current or former heavy smokers, and some researchers described the relationship between CPFE and connective tissue diseases. To our best knowledge, this was the first report of lung cancer in patient with anti-ARS antibody-positive CPFE. In some anti-ARS antibody-positive patients, smoking might have a relationship with development of CPFE and lung cancer.</p>
</abstract>

A 59-year-old man who had smoked for 23 pack-years was admitted to our hospital because of two-month history of back pain. The chest computed tomography scan demonstrated combined pulmonary fibrosis and emphysema (CPFE) and an irregular shaped nodule in the left lower lobe of the lung. A biopsy obtained from samples from subcarinal lymph nodes revealed non-small cell lung cancer. Anti-aminoacyl-tRNA synthetase (ARS) antibody was elevated up to 166 U/mL, although he had no symptoms suggestive connective tissue diseases. It is well known that most of CPFE patients are current or former heavy smokers, and some researchers described the relationship between CPFE and connective tissue diseases. To our best knowledge, this was the first report of lung cancer in patient with anti-ARS antibody-positive CPFE. In some anti-ARS antibody-positive patients, smoking might have a relationship with development of CPFE and lung cancer.

Lung cancer and combined pulmonary fibrosis and emphysema with anti-ARS antibody

Division of Respiratory Medicine, University of Tsukuba

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Lung cancer and combined pulmonary fibrosis and emphysema with anti-ARS antibody"}

A 59-year-old man who had smoked for 23 pack-years was admitted to our hospital because of two-month history of back pain. The chest computed tomography scan...

Lung cancer and combined pulmonary fibrosis and emphysema with anti-ARS antibody

Published Online: Sep 22, 2022

Page range: 193 - 196

Received: May 22, 2021

DOI: https://doi.org/10.2478/rjim-2022-0008

Keywords
non-small cell lung cancer, anti-aminoacyl-tRNA synthetase antibody, combined pulmonary fibrosis and emphysema, smoking

© 2022 Riho Tanimura et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Lung cancer and combined pulmonary fibrosis and emphysema with anti-ARS antibody

Published Online: Sep 22, 2022

Page range: 193 - 196

Received: May 22, 2021

DOI: https://doi.org/10.2478/rjim-2022-0008

Keywordsnon-small cell lung cancer, anti-aminoacyl-tRNA synthetase antibody, combined pulmonary fibrosis and emphysema, smoking

© 2022 Riho Tanimura et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
non-small cell lung cancer, anti-aminoacyl-tRNA synthetase antibody, combined pulmonary fibrosis and emphysema, smoking