<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Acute myelogenous leukemia is a multi-step hematological malignancy, affecting function, growth, proliferation and cell cycle of myeloid precursors. Overall assessment of patients with the disease requires among everything else, a comprehensive investigation of the genetic basis through various methods such as cytogenetic and molecular-genetic ones. This clarification provides diagnostic refinement and carries prognostic and predictive value in respect of essential therapeutic choices.</p><p>With this review of the literature, we focus on summarizing the latest recommendations and preferred genetic methods, as well as on emphasizing on their general benefits and limitations. Since none of these methods is actually totipotent, we also aim to shed light over the often-difficult choice of appropriate genetic analyses.</p></abstract>

Acute myelogenous leukemia is a multi-step hematological malignancy, affecting function, growth, proliferation and cell cycle of myeloid precursors. Overall assessment of patients with the disease requires among everything else, a comprehensive investigation of the genetic basis through various methods such as cytogenetic and molecular-genetic ones. This clarification provides diagnostic refinement and carries prognostic and predictive value in respect of essential therapeutic choices.With this review of the literature, we focus on summarizing the latest recommendations and preferred genetic methods, as well as on emphasizing on their general benefits and limitations. Since none of these methods is actually totipotent, we also aim to shed light over the often-difficult choice of appropriate genetic analyses.

Acute myelogenous leukemia – current recommendations and approaches in molecular-genetic assessment

Department of Medical Genetics, Faculty of Medicine

Department of Internal Diseases, Faculty of Medicine

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Acute myelogenous leukemia is a multi-step hematological malignancy, affecting function, growth, proliferation and cell cycle of myeloid precursors. Overall...

Acute myelogenous leukemia – current recommendations and approaches in molecular-genetic assessment

Published Online: Jun 14, 2022

Page range: 103 - 114

Received: Dec 10, 2021

DOI: https://doi.org/10.2478/rjim-2022-0004

Keywords
leukemia, myeloid, acute, genetic markers, genetic techniques, diagnosis, prognosis

© 2022 Dinnar Yahya et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Acute myelogenous leukemia – current recommendations and approaches in molecular-genetic assessment

Published Online: Jun 14, 2022

Page range: 103 - 114

Received: Dec 10, 2021

DOI: https://doi.org/10.2478/rjim-2022-0004

Keywordsleukemia, myeloid, acute, genetic markers, genetic techniques, diagnosis, prognosis

© 2022 Dinnar Yahya et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
leukemia, myeloid, acute, genetic markers, genetic techniques, diagnosis, prognosis