<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Celiac disease is an immune-mediated illness to gluten exposure in genetically susceptible patients. It is characterized by chronic lymphocytic inflammation of the small bowel leading to villous atrophy and its associated complications. The global prevalence of celiac disease is increasing, due in part to improved screening tests and simplified diagnostic criteria. Novel therapies are being developed and include proteolytic enzymes, sequestering agents, and immunotherapies. A strict gluten-free diet, however, remains the mainstay of treatment. In this comprehensive review, we discuss the epidemiology, definitions, diagnosis, and treatment of celiac disease.</p></abstract>

Celiac disease is an immune-mediated illness to gluten exposure in genetically susceptible patients. It is characterized by chronic lymphocytic inflammation of the small bowel leading to villous atrophy and its associated complications. The global prevalence of celiac disease is increasing, due in part to improved screening tests and simplified diagnostic criteria. Novel therapies are being developed and include proteolytic enzymes, sequestering agents, and immunotherapies. A strict gluten-free diet, however, remains the mainstay of treatment. In this comprehensive review, we discuss the epidemiology, definitions, diagnosis, and treatment of celiac disease.

Systematic approach to celiac disease: a comprehensive review for primary providers

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Celiac disease is an immune-mediated illness to gluten exposure in genetically susceptible patients. It is characterized by chronic lymphocytic inflammation of...

Systematic approach to celiac disease: a comprehensive review for primary providers

Published Online: Jun 14, 2022

Page range: 93 - 102

Received: Dec 06, 2021

DOI: https://doi.org/10.2478/rjim-2022-0002

Keywords
celiac disease, gluten sensitivity, gluten-free diet, primary care, diagnosis

© 2022 Pedro Cortés et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Systematic approach to celiac disease: a comprehensive review for primary providers

Published Online: Jun 14, 2022

Page range: 93 - 102

Received: Dec 06, 2021

DOI: https://doi.org/10.2478/rjim-2022-0002

Keywordsceliac disease, gluten sensitivity, gluten-free diet, primary care, diagnosis

© 2022 Pedro Cortés et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
celiac disease, gluten sensitivity, gluten-free diet, primary care, diagnosis